Wilms Tumor
Also covered as: hypertension · neuroblastoma · favorable histology Wilms tumor · cardiovascular disease · breast cancer · anaplastic Wilms tumor · unilateral Wilms tumor · renal dysfunction
Educational content from recorded physician discussions — not medical advice. Always talk to your child's care team about your child's situation.
Answers come only from this collection's statement ledger and cite the exact moment · not medical advice
Content of this collection
Foundations
3 items
Wilms Tumor
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Dr. Andrew Davidoff, chairman of surgery at St. Jude Children's, joins Dr. Rae Hanke to review the essentials of Wilms tumor in this videocast.
video · May 2020
Topics in 10: Wilms Tumor
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Drs Andrew Davidoff, Todd Ponsky and Rae Hanke come together to provide you the essentials on the diagnosis and management of Wilms Tumor.Intro and outro tracks are adapted from "I dunno" by grapes, featuring J Lang, Morusque. Artist URL: c
podcast · 12:29 · Dec 2020
Hepatoblastoma with Dr. Greg Tiao
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Hepatoblastoma is the most common malignant liver tumor in the pediatric population. But treatment strategies have changed dramatically over the past 25 years. That’s why today, were going to review the basics-with an expert.
00:27:38-0027:
video · Mar 2022
Medical Management
1 item
Update Course Rewind: Updates in Wilms Management 2024
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In this session from the 12th Annual Update Course in Pediatric Surgery, Dr. Bhargava Mullapudi (Children’s Mercy Kansas City) presents updated strategies in Wilms tumor management, exploring how tumor biology and global guidelines are shap
video · 4:07 · Sep 2025
Complications
1 item
Long-Term Follow-Up of Surgical Outcomes for Patients With Wilms Tumor and Neuroblastoma
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Jo Cooke-Barber, Federico Scorletti, Beth Rymeski, Debra Eshelman-Kent, Rajaram Nagarajan, Karen Burns, Todd Jenkins, Roshni DasguptaBackground: There are minimal data on long-term surgical outcomes of patients who have undergone resection
video · 1:04 · Feb 2026
Evidence & Research
9 items
Wilms Tumor Protocol Violations: Practice Gap discussion at Update Course 2018
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At the 6th Annual Pediatric Surgery Update Course, Drs Charles Snyder, Craig Lillehei and David Powell discussthe top ten practice gaps of 2018. Here they discuss Wilms Tumor Protocol violations, focusing on ipsilateral lymph node sampling,
video · 9:55 · Sep 2018
Wilms Tumor Protocol Violations: 2018 Pediatric Surgery Practice Gap #3
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Drs. Todd Ponsky, Alex Casar, Alex Gibbons, and Rae Hanke review 2018 Practice Gap #3: Wilms Tumor Protocol Violations, as identified by the APSA Professional Development Committee.
video · Jun 2019
Non-Operative Management of Appendicitis: 2018 Pediatric Surgery Practice Gap #2
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Drs. Todd Ponsky, Alex Casar, Alex Gibbons, and Rae Hanke review 2018 Practice Gap #2: Wilms Tumor Protocol Violations, as identified by the APSA Professional Development Committee.
video · 1:21 · Jun 2019
Journal of Pediatric Surgery Article Highlights: April 2022
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We're back with the April issue of JPS article highlights. This time we're talking to Dr. Paul Tam and authors Dr. Natalie Lopyan and Dr. Christina Theodorou. Hosts: Em Tombash, Rod Gerardo, Brittany Levy Lopyan NM, Perrone EE, Gadepalli SK
podcast · 8:38 · Jul 2022
Efficacy and late kidney effects of nephron-sparing surgery in the management of unilateral Wilms tumor
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Newarticle you should know by Cecilia Gigena
"Efficacy and late kidney effects of nephron-sparing surgery in the management of unilateral Wilms tumor: a systematic review and meta-analysis"
Authors: Shan Li, Jinkui Wang, Mujie Li, Zha
video · 0:53 · Mar 2024
Eficacia y efectos renales tardíos de la cirugía conservadora de nefronas en el tratamiento del tumor de Wilms unilateral: una revisión sistemática y un metanálisis
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Nuevo articulo que tienes que conocer por la Dra. Cecilia Gigena
"Eficacia y efectos renales tardíos de la cirugía conservadora de nefronas en el tratamiento del tumor de Wilms unilateral: una revisión sistemática y un metanálisis"
Au
video · 1:02 · Mar 2024
Quick Literature Updates Ep 21
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We’re back with 21st episode of "Quick Literature Updates" the podcast series that delivers the latest updates in pediatric surgery literature in a quick and digestible format. In each episode, we review articles covering the most interesti
video · 4:04 · Sep 2025
Social Determinants of Health Influence on Survival in Wilms Tumor, Neuroblastoma, and Hepatoblastoma
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Colleen P Nofi, Bailey K Roberts, Erin G Brown, Barrie S Rich, Meera Kotagal, & Richard D Glick Background: The influence of social determinants of health (SDOH) on childhood cancer outcomes is complex and understudied. This study aimed to
video · 1:06 · Jan 2026
Impact of Pulmonary Tumor Burden in Favorable Histology Wilms Tumor Outcomes: A Report From the Children's Oncology Group Study AREN053
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David B Dix Geetika Khanna, Lindsay A Renfro, Ian C Tfirn, Ethan A Smith, Maddy Artunduaga, Meryle J Eklund, Jesse K Sandberg, Lauren N Parsons, John A Kalapurakal, Peter F Ehrlich, Jennifer H Aldrink, Richard D Glick, Daniel J Benedetti, C
video · 1:15 · Mar 2026
Case-Based Learning
3 items
Compiled Sandler Rapid Fire Sessions: Update Course 2015
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Dr. Anthony Sandler from Children's National Medical Center leads the discussion in a rapid fire format for multiple cases, including management of Wilms tumor, gastroschisis, and complex ileal atresia.
video · 29:44 · Jan 2019
Wilms Tumor Rapid Fire: Update Course 2015
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Dr. Anthony Sandler from Children's National Medical Center discusses management of Wilms tumor, including bilateral disease and when to pursue chemotherapy vs. operative intervention.
video · 8:46 · Jan 2019
Neuroblastoma
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Drs Erika Newman, Dan von Allmen and Tony Sandler join Dr. Todd Ponsky in a discussion covering the latest in neuroblastoma. Contributing editor: Rachel (Rae) Hanke, MD
Case 1: Mother who presents with 26 week fetus
with a pr
podcast · 56:19 · Dec 2020
In-Depth Reviews
2 items
Wilms Tumor: Audio Chapter
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An interactive discussion about Wilms tumor between Todd Ponsky, MD, Avraham Schlager, and Peter Ehrlich, MD.Dr. Peter Ehrlich is a professor of pediatrics surgery at the University of Michigan C.S. Mott Children’s Hospital who is also a vi
podcast · 64:03 · Jan 2019
Wilms Tumor: Audio Chapter
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An interactive discussion about Wilms tumor between Todd Ponsky, MD, Avraham Schlager, and Peter Ehrlich, MD.Dr. Peter Ehrlich is a professor of pediatrics surgery at the University of Michigan C.S. Mott Children’s Hospital who is also a vi
podcast · 64:03 · Jan 2021
Emerging & Future Directions
1 item
Updated Favorable histology Wilms tumor risk stratification: Rationale for future Children’s Oncology Group clinical trials
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Daniel J Benedetti, Nicholas G Cost, Peter F Ehrlich, Nicholas Evageliou, Elizabeth Fialkowski, Lauren N Parsons, Kelly L Vallance, Lindsay A Renfro, Andrew L Hong, Jennifer H Aldrink, Luke Pater, Arnold C Paulino, Jesse K Sandberg, Ethan A
video · 0:53 · Apr 2026
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Every statement below comes from the recorded discussions, with its speaker and moment.
Long-Term Follow-Up of Surgical Outcomes for Patients With Wilms Tumor and Neuroblastoma
This single institution cohort followed survivors for a mean of 27 years after open oncologic resection for Wilms tumor and neuroblastoma
epidemiologicalSophia Schermerhorn0:11 ↗
14% of patients required a repeat laparotomy
epidemiologicalSophia Schermerhorn0:20 ↗
The most common indications for repeat laparotomy were small bowel obstruction or tumor recurrence
clinicalSophia Schermerhorn0:21 ↗
In Wilms tumor, obstruction typically occurred within the first year
clinicalSophia Schermerhorn0:26 ↗
In neuroblastoma, obstruction often developed more than a decade later, well beyond routine follow-up
clinicalSophia Schermerhorn0:29 ↗
Radiation dose was not associated with re-operation risk
clinicalSophia Schermerhorn0:34 ↗
Secondary malignancy was uncommon in this cohort
epidemiologicalSophia Schermerhorn0:37 ↗
Hypertension after nephrectomy was not increased compared to population norms
clinicalSophia Schermerhorn0:37 ↗
Scoliosis occurred in roughly 10 to 13% of patients, higher than the general population
epidemiologicalSophia Schermerhorn0:45 ↗
Scoliosis has multi-factorial contributors including surgery and possibly radiation
clinicalSophia Schermerhorn0:45 ↗
Even decades after treatment, these patients remain at risk for late complications that warrant long-term counseling and follow-up
guidelineSophia Schermerhorn0:58 ↗
Impact of Pulmonary Tumor Burden in Favorable Histology Wilms Tumor Outcomes: A Report From the Children's Oncology Group Study AREN053
Dick et al. published a report from a Children's Oncology Group study in the Journal of Clinical Oncology in 2025
clinicalJill Knepprath0:14 ↗
The study examined factors in patients with favorable histology Wilms tumor and pulmonary metastases and how those factors may affect outcomes
clinicalJill Knepprath0:19 ↗
Factors studied included the number of metastases, the size of the metastases, and different biological markers
clinicalJill Knepprath0:30 ↗
There was no difference in survival based on the number of metastases
clinicalJill Knepprath0:36 ↗
Patients who had a rapid response to chemotherapy with larger nodules showed worse event-free survival
clinicalJill Knepprath0:41 ↗
Patients with larger nodules and rapid response to chemotherapy showed no changes in overall survival
clinicalJill Knepprath0:41 ↗
In multivariable models, neither the size nor the number of nodules had any effect on survival
clinicalJill Knepprath0:49 ↗
1q gain was associated with worse event-free survival
clinicalJill Knepprath0:55 ↗
1q gain was associated with worse overall survival
clinicalJill Knepprath0:55 ↗
1q gain is the superior prognostic factor when compared to size and number of nodules in patients with favorable histology Wilms tumor and pulmonary metastases
clinicalJill Knepprath1:04 ↗
Updated Favorable histology Wilms tumor risk stratification: Rationale for future Children’s Oncology Group clinical trials
Risk stratification for Wilms tumor has evolved many times over the years.
clinicalJill Knera0:00 ↗
The Children's Oncology Group published updated risk stratification for patients with favorable histology Wilms tumor in Nature in June 2025.
guidelineJill Knera0:09 ↗
The new risk stratification model includes biological and clinical features that were not in the first generation risk stratification.
guidelineJill Knera0:19 ↗
The new model changes some of the older features or gets rid of them altogether.
guidelineJill Knera0:27 ↗
Factors being added are loss of heterozygosity of 11P15, 1Q gain, and lymph node involvement.
guidelineJill Knera0:32 ↗
Tumor nephrectomy weight is no longer included in the risk stratification.
guidelineJill Knera0:41 ↗
The model modified how histology and age are used to stratify certain patients.
guidelineJill Knera0:43 ↗
More changes are expected in the future as ongoing COG trials produce more results.
opinionJill Knera0:48 ↗
Wilms Tumor: Audio Chapter
In North America, the preferred approach for most renal tumors is primary total nephrectomy with ureterectomy and lymph node sampling
guidelinePeter Ehrlich6:23 ↗