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Impact of Pulmonary Tumor Burden in Favorable Histology Wilms Tumor Outcomes: A Report From the Children's Oncology Group Study AREN053
hosted by Dr. Jill Knepprath
Chapter 1 of 1 · Evidence & Research
Prognostic Factors in Favorable Histology Wilms Tumor with Lung Metastases
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What the experts said
Dick et al. published a report from a Children's Oncology Group study in the Journal of Clinical Oncology in 2025
The study examined factors in patients with favorable histology Wilms tumor and pulmonary metastases and how those factors may affect outcomes
Factors studied included the number of metastases, the size of the metastases, and different biological markers
There was no difference in survival based on the number of metastases
Patients who had a rapid response to chemotherapy with larger nodules showed worse event-free survival
Patients with larger nodules and rapid response to chemotherapy showed no changes in overall survival
In multivariable models, neither the size nor the number of nodules had any effect on survival
1q gain was associated with worse event-free survival
1q gain was associated with worse overall survival
1q gain is the superior prognostic factor when compared to size and number of nodules in patients with favorable histology Wilms tumor and pulmonary metastases