The numbers that I quote the families from that original study is that of the, I think it was 84 patients that they observed, 16 underwent resection for either growth or some other reason.
The numbers that I quote the families from that original study is that of the, I think it was 84 patients that they observed, 16 underwent resection for either growth or some other reason.
The numbers that I quote the families from that original study is that of the, I think it was 84 patients that they observed, 16 underwent resection for either growth or some other reason.
The numbers that I quote the families from that original study is that of the, I think it was 84 patients that they observed, 16 underwent resection for either growth or some other reason.
The numbers that I quote the families from that original study is that of the, I think it was 84 patients that they observed, 16 underwent resection for either growth or some other reason.
I sort of think of it like imperforate anus. And you think of it as there's different ways of classifying imperforate anus. But for me, practically, there's high and there's low.
guidelineCurrent protocol for bilateral Wilms is to start chemotherapy without biopsy, typically 2 cycles, and stop when tumor shrinkage plateaus (defined as less than 50% volume reduction)↗
▶Ep 4 · 4:30
clinicalWhen bilateral Wilms tumors stop shrinking after chemotherapy, it is usually due to mesenchymal differentiation rather than anaplastic transformation↗
▶Ep 4 · 4:53
clinicalBilateral nephron-sparing surgery for Wilms can be performed using on-ice technique with vascular clamping and sharp dissection↗
▶Ep 4 · 5:58
quoteI never like to stick around for post-op complications.↗
▶Ep 4 · 7:56
quoteWas, was the anaplasia there initially or secondary chemotherapy, did it differentiate into an anaplastic phenotype?↗
▶Ep 4 · 9:12
epidemiological97% of bilateral kidney tumors in children are Wilms tumor↗
▶Ep 4 · 13:05
clinicalIf gastroschisis fascia is not cut during closure, umbilical hernias will typically close spontaneously and do not require repair↗
▶Ep 4 · 15:06
clinicalTegaderm dressing for gastroschisis is typically left in place for 3 days, then converted to dry dressing when bowel is adherent↗
▶Ep 4 · 16:08
clinicalFeeding can be started in gastroschisis when bowel function returns, without waiting for complete fascial closure↗
▶Ep 4 · 19:14
clinicalGastroschisis with atresia typically presents with pristine bowel at the atresia site, unlike inflamed gastroschisis bowel↗
▶Ep 4 · 19:26
clinicalAmbient intra-abdominal pressure is lower when gastroschisis fascia is not closed compared to fascial closure↗
▶Ep 4 · 21:09
quoteYou cannot tell what's going on with this bowel, whatever you, whatever you do.↗
clinicalGastroschisis bowel can transform from inflamed appearance to normal intestine within 2 weeks, earlier than the traditional 4-6 week teaching↗
▶Ep 4 · 28:12
clinicalIn neonates with questionable short gut, plication is preferred over tapering to preserve bowel for potential future lengthening procedures↗
Compiled Sandler Rapid Fire Sessions: Update Course 2015
▶Ep 8 · 0:28
quoteI congratulate you for putting on an incredible symposium↗
▶Ep 8 · 1:32
guidelineFor bilateral Wilms tumors, chemotherapy is started without biopsy and continued until tumor shrinkage stops, typically defined as less than 50% volume reduction↗
▶Ep 8 · 4:19
clinicalWhen bilateral Wilms tumors stop shrinking with chemotherapy, it is usually due to mesenchymal differentiation rather than anaplastic transformation↗
▶Ep 8 · 4:44
clinicalBilateral nephron-sparing surgery is achievable in most cases of large bilateral Wilms tumors using on-table renal hypothermia with ice and vascular clamping↗
▶Ep 8 · 5:58
quoteI never like to stick around for post-op complications. I, I'm that's a joke, sorry.↗
▶Ep 8 · 7:56
opinionMost pathologists believe anaplasia in Wilms tumor is present primarily rather than induced by chemotherapy↗
▶Ep 8 · 7:56
quoteWas, was the anaplasia there initially or secondary chemotherapy, did it differentiate into an anaplastic phenotype?↗
▶Ep 8 · 9:12
epidemiological97% of bilateral large kidney tumors in children are Wilms tumor↗
▶Ep 8 · 12:54
clinicalFor gastroschisis closure without fascial incision, umbilical hernias that develop will typically close spontaneously over 3-5 years↗
▶Ep 8 · 15:06
clinicalTegaderm dressing is left in place for approximately 3 days on gastroschisis closures, then converted to dry dressing when adherent↗
▶Ep 8 · 16:08
clinicalFeeding can be started when bowel function returns in gastroschisis cases, without waiting for complete fascial closure↗
▶Ep 8 · 19:14
clinicalIn gastroschisis with unclear atresia and inflamed bowel, reduction without anastomosis is preferred, with re-exploration at 4-6 weeks↗
▶Ep 8 · 19:26
clinicalClosing fascia in gastroschisis increases intra-abdominal pressure compared to leaving it open with Tegaderm coverage↗
▶Ep 8 · 22:07
clinicalRe-exploration at 2 weeks in complex gastroschisis can show transformation of inflamed bowel into viable intestine suitable for anastomosis↗
▶Ep 8 · 25:19
clinicalFor apple peel ileal atresia with ischemic distal bowel, resection is indicated rather than waiting for reperfusion if bowel does not pink up on the operating table↗
▶Ep 8 · 28:10
clinicalPlication of dilated proximal bowel in neonatal atresia is preferred over tapering to preserve bowel length for potential future lengthening procedures↗
epidemiologicalFamilial neuroblastoma occurs in about 1% of patients↗
▶Ep 2 · 9:09
quoteThe numbers that I quote the families from that original study is that of the, I think it was 84 patients that they observed, 16 underwent resection for either growth or some other reason.↗
▶Ep 2 · 9:09
clinicalOf 84 prenatally diagnosed cases observed in the GetNucturne study, 16 (about 20%) underwent resection, with 98% event-free survival and 100% overall survival↗
▶Ep 2 · 11:03
quoteI will say the last one of these that I had at the 12-month scans, it got bigger. And we took it out and it ended up being a sequestration.↗
▶Ep 2 · 12:31
opinionFive centimeters is used as a size threshold for considering surgical resection of observed neuroblastoma↗
▶Ep 2 · 16:32
clinicalClassic findings of stage MS include high urine catecholamines, blue blebs on skin, liver metastases, and adrenal mass↗
▶Ep 2 · 23:50
clinicalOpen biopsy allows adequate tissue for NMYC amplification, ALK mutation, and ploidy studies↗
▶Ep 2 · 31:38
quoteI sort of think of it like imperforate anus. And you think of it as there's different ways of classifying imperforate anus. But for me, practically, there's high and there's low.↗
▶Ep 2 · 31:38
clinicalNMYC amplification automatically makes neuroblastoma high-risk regardless of other factors↗
▶Ep 2 · 32:40
quoteLook at NMEC amplification. It's either up, it's either amplified or it's non-amplified. And if it's amplified, it's high-risk disease, period.↗
▶Ep 2 · 35:25
guidelineAge cutoff for risk stratification is now 18 months rather than 12 months↗
▶Ep 2 · 45:31
clinicalHigh-risk neuroblastoma responds well to chemotherapy due to high proliferative rate↗
▶Ep 2 · 45:31
clinicalStem cell harvesting for high-risk neuroblastoma is usually after the second cycle of chemotherapy↗
▶Ep 2 · 46:00
clinicalRecent German/European publication stated that amount of local disease resection does not make a difference in outcome↗
▶Ep 2 · 46:40
clinicalPatients with high-risk neuroblastoma die of systemic metastatic disease, not local disease↗
▶Ep 2 · 46:40
quotePatients don't die of local disease. They die of systemic disease, in neuroblastoma.↗
▶Ep 2 · 53:13
clinicalNephrectomy should be avoided in neuroblastoma surgery because it requires reduction of chemotherapy doses↗
▶Ep 2 · 53:44
clinicalMonoclonal antibody against ganglioside GD2 improved two-year survival in high-risk neuroblastoma from 46% to 60%↗
▶Ep 2 · 54:40
quoteThe first breakthrough that we've had in any childhood cancer with immunotherapy was the antibody, the monoclonal antibody against ganglioside GD2.↗
▶Ep 2 · 54:40
clinicalCheckpoint inhibitors have not been successful in neuroblastoma because it is not an immunogenic tumor↗
epidemiologicalFamilial neuroblastoma occurs in about 1% of patients↗
▶Ep 74 · 9:09
quoteThe numbers that I quote the families from that original study is that of the, I think it was 84 patients that they observed, 16 underwent resection for either growth or some other reason.↗
▶Ep 74 · 9:09
clinicalOf 84 prenatally diagnosed cases observed in the GetNucturne study, 16 (about 20%) underwent resection, with 98% event-free survival and 100% overall survival↗
▶Ep 74 · 11:03
quoteI will say the last one of these that I had at the 12-month scans, it got bigger. And we took it out and it ended up being a sequestration.↗
▶Ep 74 · 12:31
opinionFive centimeters is used as a size threshold for considering surgical resection of observed neuroblastoma↗
▶Ep 74 · 16:32
clinicalClassic findings of stage MS include high urine catecholamines, blue blebs on skin, liver metastases, and adrenal mass↗
▶Ep 74 · 23:50
clinicalOpen biopsy allows adequate tissue for NMYC amplification, ALK mutation, and ploidy studies↗
▶Ep 74 · 31:38
quoteI sort of think of it like imperforate anus. And you think of it as there's different ways of classifying imperforate anus. But for me, practically, there's high and there's low.↗
▶Ep 74 · 31:38
clinicalNMYC amplification automatically makes neuroblastoma high-risk regardless of other factors↗
▶Ep 74 · 32:40
quoteLook at NMEC amplification. It's either up, it's either amplified or it's non-amplified. And if it's amplified, it's high-risk disease, period.↗
▶Ep 74 · 35:25
guidelineAge cutoff for risk stratification is now 18 months rather than 12 months↗
▶Ep 74 · 45:31
clinicalHigh-risk neuroblastoma responds well to chemotherapy due to high proliferative rate↗
▶Ep 74 · 45:31
clinicalStem cell harvesting for high-risk neuroblastoma is usually after the second cycle of chemotherapy↗
▶Ep 74 · 46:00
clinicalRecent German/European publication stated that amount of local disease resection does not make a difference in outcome↗
▶Ep 74 · 46:40
quotePatients don't die of local disease. They die of systemic disease, in neuroblastoma.↗
▶Ep 74 · 46:40
clinicalPatients with high-risk neuroblastoma die of systemic metastatic disease, not local disease↗
▶Ep 74 · 53:13
clinicalNephrectomy should be avoided in neuroblastoma surgery because it requires reduction of chemotherapy doses↗
▶Ep 74 · 53:44
clinicalMonoclonal antibody against ganglioside GD2 improved two-year survival in high-risk neuroblastoma from 46% to 60%↗
▶Ep 74 · 54:40
clinicalCheckpoint inhibitors have not been successful in neuroblastoma because it is not an immunogenic tumor↗
▶Ep 74 · 54:40
quoteThe first breakthrough that we've had in any childhood cancer with immunotherapy was the antibody, the monoclonal antibody against ganglioside GD2.↗
guidelineCurrent protocol for bilateral Wilms is to start chemotherapy without biopsy, typically 2 cycles, and stop when tumor shrinkage plateaus (defined as less than 50% volume reduction)↗
▶Ep 5 · 4:30
clinicalWhen bilateral Wilms tumors stop shrinking after chemotherapy, it is usually due to mesenchymal differentiation rather than anaplastic transformation↗
▶Ep 5 · 4:53
clinicalBilateral nephron-sparing surgery for Wilms can be performed using on-ice technique with vascular clamping and sharp dissection↗
▶Ep 5 · 5:58
quoteI never like to stick around for post-op complications.↗
▶Ep 5 · 7:56
quoteWas, was the anaplasia there initially or secondary chemotherapy, did it differentiate into an anaplastic phenotype?↗
▶Ep 5 · 9:12
epidemiological97% of bilateral kidney tumors in children are Wilms tumor↗
▶Ep 5 · 13:05
clinicalIf gastroschisis fascia is not cut during closure, umbilical hernias will typically close spontaneously and do not require repair↗
▶Ep 5 · 15:06
clinicalTegaderm dressing for gastroschisis is typically left in place for 3 days, then converted to dry dressing when bowel is adherent↗
▶Ep 5 · 16:08
clinicalFeeding can be started in gastroschisis when bowel function returns, without waiting for complete fascial closure↗
▶Ep 5 · 19:14
clinicalGastroschisis with atresia typically presents with pristine bowel at the atresia site, unlike inflamed gastroschisis bowel↗
▶Ep 5 · 19:26
clinicalAmbient intra-abdominal pressure is lower when gastroschisis fascia is not closed compared to fascial closure↗
▶Ep 5 · 21:09
quoteYou cannot tell what's going on with this bowel, whatever you, whatever you do.↗
clinicalGastroschisis bowel can transform from inflamed appearance to normal intestine within 2 weeks, earlier than the traditional 4-6 week teaching↗
▶Ep 5 · 28:12
clinicalIn neonates with questionable short gut, plication is preferred over tapering to preserve bowel for potential future lengthening procedures↗
Compiled Sandler Rapid Fire Sessions: Update Course 2015
▶Ep 12 · 0:28
quoteI congratulate you for putting on an incredible symposium↗
▶Ep 12 · 1:32
guidelineFor bilateral Wilms tumors, chemotherapy is started without biopsy and continued until tumor shrinkage stops, typically defined as less than 50% volume reduction↗
▶Ep 12 · 4:19
clinicalWhen bilateral Wilms tumors stop shrinking with chemotherapy, it is usually due to mesenchymal differentiation rather than anaplastic transformation↗
▶Ep 12 · 4:44
clinicalBilateral nephron-sparing surgery is achievable in most cases of large bilateral Wilms tumors using on-table renal hypothermia with ice and vascular clamping↗
▶Ep 12 · 5:58
quoteI never like to stick around for post-op complications. I, I'm that's a joke, sorry.↗
▶Ep 12 · 7:56
opinionMost pathologists believe anaplasia in Wilms tumor is present primarily rather than induced by chemotherapy↗
▶Ep 12 · 7:56
quoteWas, was the anaplasia there initially or secondary chemotherapy, did it differentiate into an anaplastic phenotype?↗
▶Ep 12 · 9:12
epidemiological97% of bilateral large kidney tumors in children are Wilms tumor↗
▶Ep 12 · 12:54
clinicalFor gastroschisis closure without fascial incision, umbilical hernias that develop will typically close spontaneously over 3-5 years↗
▶Ep 12 · 15:06
clinicalTegaderm dressing is left in place for approximately 3 days on gastroschisis closures, then converted to dry dressing when adherent↗
▶Ep 12 · 16:08
clinicalFeeding can be started when bowel function returns in gastroschisis cases, without waiting for complete fascial closure↗
▶Ep 12 · 19:14
clinicalIn gastroschisis with unclear atresia and inflamed bowel, reduction without anastomosis is preferred, with re-exploration at 4-6 weeks↗
▶Ep 12 · 19:26
clinicalClosing fascia in gastroschisis increases intra-abdominal pressure compared to leaving it open with Tegaderm coverage↗
▶Ep 12 · 22:07
clinicalRe-exploration at 2 weeks in complex gastroschisis can show transformation of inflamed bowel into viable intestine suitable for anastomosis↗
▶Ep 12 · 25:19
clinicalFor apple peel ileal atresia with ischemic distal bowel, resection is indicated rather than waiting for reperfusion if bowel does not pink up on the operating table↗
▶Ep 12 · 28:10
clinicalPlication of dilated proximal bowel in neonatal atresia is preferred over tapering to preserve bowel length for potential future lengthening procedures↗
guidelineCurrent protocol for bilateral Wilms is to start chemotherapy without biopsy, typically 2 cycles, and stop when tumor shrinkage plateaus (defined as less than 50% volume reduction)↗
▶Ep 6 · 4:30
clinicalWhen bilateral Wilms tumors stop shrinking after chemotherapy, it is usually due to mesenchymal differentiation rather than anaplastic transformation↗
▶Ep 6 · 4:53
clinicalBilateral nephron-sparing surgery for Wilms can be performed using on-ice technique with vascular clamping and sharp dissection↗
▶Ep 6 · 5:58
quoteI never like to stick around for post-op complications.↗
▶Ep 6 · 7:56
quoteWas, was the anaplasia there initially or secondary chemotherapy, did it differentiate into an anaplastic phenotype?↗
▶Ep 6 · 9:12
epidemiological97% of bilateral kidney tumors in children are Wilms tumor↗
▶Ep 6 · 13:05
clinicalIf gastroschisis fascia is not cut during closure, umbilical hernias will typically close spontaneously and do not require repair↗
▶Ep 6 · 15:06
clinicalTegaderm dressing for gastroschisis is typically left in place for 3 days, then converted to dry dressing when bowel is adherent↗
▶Ep 6 · 16:08
clinicalFeeding can be started in gastroschisis when bowel function returns, without waiting for complete fascial closure↗
▶Ep 6 · 19:14
clinicalGastroschisis with atresia typically presents with pristine bowel at the atresia site, unlike inflamed gastroschisis bowel↗
▶Ep 6 · 19:26
clinicalAmbient intra-abdominal pressure is lower when gastroschisis fascia is not closed compared to fascial closure↗
▶Ep 6 · 21:09
quoteYou cannot tell what's going on with this bowel, whatever you, whatever you do.↗
clinicalGastroschisis bowel can transform from inflamed appearance to normal intestine within 2 weeks, earlier than the traditional 4-6 week teaching↗
▶Ep 6 · 28:12
clinicalIn neonates with questionable short gut, plication is preferred over tapering to preserve bowel for potential future lengthening procedures↗
Compiled Sandler Rapid Fire Sessions: Update Course 2015
▶Ep 19 · 0:28
quoteI congratulate you for putting on an incredible symposium↗
▶Ep 19 · 1:32
guidelineFor bilateral Wilms tumors, chemotherapy is started without biopsy and continued until tumor shrinkage stops, typically defined as less than 50% volume reduction↗
▶Ep 19 · 4:19
clinicalWhen bilateral Wilms tumors stop shrinking with chemotherapy, it is usually due to mesenchymal differentiation rather than anaplastic transformation↗
▶Ep 19 · 4:44
clinicalBilateral nephron-sparing surgery is achievable in most cases of large bilateral Wilms tumors using on-table renal hypothermia with ice and vascular clamping↗
▶Ep 19 · 5:58
quoteI never like to stick around for post-op complications. I, I'm that's a joke, sorry.↗
▶Ep 19 · 7:56
quoteWas, was the anaplasia there initially or secondary chemotherapy, did it differentiate into an anaplastic phenotype?↗
▶Ep 19 · 7:56
opinionMost pathologists believe anaplasia in Wilms tumor is present primarily rather than induced by chemotherapy↗
▶Ep 19 · 9:12
epidemiological97% of bilateral large kidney tumors in children are Wilms tumor↗
▶Ep 19 · 12:54
clinicalFor gastroschisis closure without fascial incision, umbilical hernias that develop will typically close spontaneously over 3-5 years↗
▶Ep 19 · 15:06
clinicalTegaderm dressing is left in place for approximately 3 days on gastroschisis closures, then converted to dry dressing when adherent↗
▶Ep 19 · 16:08
clinicalFeeding can be started when bowel function returns in gastroschisis cases, without waiting for complete fascial closure↗
▶Ep 19 · 19:14
clinicalIn gastroschisis with unclear atresia and inflamed bowel, reduction without anastomosis is preferred, with re-exploration at 4-6 weeks↗
▶Ep 19 · 19:26
clinicalClosing fascia in gastroschisis increases intra-abdominal pressure compared to leaving it open with Tegaderm coverage↗
▶Ep 19 · 22:07
clinicalRe-exploration at 2 weeks in complex gastroschisis can show transformation of inflamed bowel into viable intestine suitable for anastomosis↗
▶Ep 19 · 25:19
clinicalFor apple peel ileal atresia with ischemic distal bowel, resection is indicated rather than waiting for reperfusion if bowel does not pink up on the operating table↗
▶Ep 19 · 28:10
clinicalPlication of dilated proximal bowel in neonatal atresia is preferred over tapering to preserve bowel length for potential future lengthening procedures↗
quoteThe priority during the pregnancy is the mom. And once the baby is born, then we'll learn more and the first thing we'll do is get more information once the baby is born.↗
▶Ep 3 · 4:39
epidemiologicalFamilial neuroblastoma occurs in about 1% of patients↗
▶Ep 3 · 5:34
guidelineCT scan or MRI not needed for 3 cm lesion unless urine catecholamines are elevated↗
▶Ep 3 · 10:39
epidemiologicalOf 84 observed patients in Nocktern study, 16 (approximately 20%) underwent resection for growth or family preference↗
▶Ep 3 · 14:36
guideline5 centimeters is used as size cutoff for surgical intervention in observed prenatal masses↗
▶Ep 3 · 22:56
clinicalUltrasound is important for Wilms tumor to assess venous extension↗
▶Ep 3 · 23:50
guidelineComplete staging workup includes bone marrow biopsy, MIBG scan, chest CT to rule out metastasis, and head CT if clinical symptoms present↗
▶Ep 3 · 23:50
clinicalLarge mass encasing aorta and celiac axis with microcalcifications represents L2 INRG classification↗
▶Ep 3 · 27:10
opinionTransperitoneal laparoscopic biopsy may not allow adequate bleeding control for large tumors↗
▶Ep 3 · 27:10
opinionOpen retroperitoneal biopsy provides adequate tissue size for pathology and biology studies↗
▶Ep 3 · 27:10
opinionMultiple percutaneous biopsies may not provide adequate tissue for biology studies↗
▶Ep 3 · 27:10
clinicalNMYC amplification can be obtained from bone marrow, but additional biology studies require tumor tissue↗
▶Ep 3 · 28:28
clinicalBiology studies beyond NMYC include ALK mutation and ploidy status↗
Neuroblastoma
▶Ep 6 · 3:27
epidemiologicalFamilial neuroblastoma occurs in about 1% of patients↗
▶Ep 6 · 9:09
clinicalOf 84 prenatally diagnosed cases observed in the GetNucturne study, 16 (about 20%) underwent resection, with 98% event-free survival and 100% overall survival↗
▶Ep 6 · 9:09
quoteThe numbers that I quote the families from that original study is that of the, I think it was 84 patients that they observed, 16 underwent resection for either growth or some other reason.↗
▶Ep 6 · 11:03
quoteI will say the last one of these that I had at the 12-month scans, it got bigger. And we took it out and it ended up being a sequestration.↗
▶Ep 6 · 12:31
opinionFive centimeters is used as a size threshold for considering surgical resection of observed neuroblastoma↗
▶Ep 6 · 16:32
clinicalClassic findings of stage MS include high urine catecholamines, blue blebs on skin, liver metastases, and adrenal mass↗
▶Ep 6 · 23:50
clinicalOpen biopsy allows adequate tissue for NMYC amplification, ALK mutation, and ploidy studies↗
▶Ep 6 · 31:38
clinicalNMYC amplification automatically makes neuroblastoma high-risk regardless of other factors↗
▶Ep 6 · 31:38
quoteI sort of think of it like imperforate anus. And you think of it as there's different ways of classifying imperforate anus. But for me, practically, there's high and there's low.↗
▶Ep 6 · 32:40
quoteLook at NMEC amplification. It's either up, it's either amplified or it's non-amplified. And if it's amplified, it's high-risk disease, period.↗
▶Ep 6 · 35:25
guidelineAge cutoff for risk stratification is now 18 months rather than 12 months↗
▶Ep 6 · 45:31
clinicalStem cell harvesting for high-risk neuroblastoma is usually after the second cycle of chemotherapy↗
▶Ep 6 · 45:31
clinicalHigh-risk neuroblastoma responds well to chemotherapy due to high proliferative rate↗
▶Ep 6 · 46:00
clinicalRecent German/European publication stated that amount of local disease resection does not make a difference in outcome↗
▶Ep 6 · 46:40
quotePatients don't die of local disease. They die of systemic disease, in neuroblastoma.↗
▶Ep 6 · 46:40
clinicalPatients with high-risk neuroblastoma die of systemic metastatic disease, not local disease↗
▶Ep 6 · 53:13
clinicalNephrectomy should be avoided in neuroblastoma surgery because it requires reduction of chemotherapy doses↗
▶Ep 6 · 53:44
clinicalMonoclonal antibody against ganglioside GD2 improved two-year survival in high-risk neuroblastoma from 46% to 60%↗
▶Ep 6 · 54:40
clinicalCheckpoint inhibitors have not been successful in neuroblastoma because it is not an immunogenic tumor↗
▶Ep 6 · 54:40
quoteThe first breakthrough that we've had in any childhood cancer with immunotherapy was the antibody, the monoclonal antibody against ganglioside GD2.↗
epidemiologicalFamilial neuroblastoma occurs in about 1% of patients↗
▶Ep 5 · 9:09
quoteThe numbers that I quote the families from that original study is that of the, I think it was 84 patients that they observed, 16 underwent resection for either growth or some other reason.↗
▶Ep 5 · 9:09
clinicalOf 84 prenatally diagnosed cases observed in the GetNucturne study, 16 (about 20%) underwent resection, with 98% event-free survival and 100% overall survival↗
▶Ep 5 · 11:03
quoteI will say the last one of these that I had at the 12-month scans, it got bigger. And we took it out and it ended up being a sequestration.↗
▶Ep 5 · 12:31
opinionFive centimeters is used as a size threshold for considering surgical resection of observed neuroblastoma↗
▶Ep 5 · 16:32
clinicalClassic findings of stage MS include high urine catecholamines, blue blebs on skin, liver metastases, and adrenal mass↗
▶Ep 5 · 23:50
clinicalOpen biopsy allows adequate tissue for NMYC amplification, ALK mutation, and ploidy studies↗
▶Ep 5 · 31:38
quoteI sort of think of it like imperforate anus. And you think of it as there's different ways of classifying imperforate anus. But for me, practically, there's high and there's low.↗
▶Ep 5 · 31:38
clinicalNMYC amplification automatically makes neuroblastoma high-risk regardless of other factors↗
▶Ep 5 · 32:40
quoteLook at NMEC amplification. It's either up, it's either amplified or it's non-amplified. And if it's amplified, it's high-risk disease, period.↗
▶Ep 5 · 35:25
guidelineAge cutoff for risk stratification is now 18 months rather than 12 months↗
▶Ep 5 · 45:31
clinicalStem cell harvesting for high-risk neuroblastoma is usually after the second cycle of chemotherapy↗
▶Ep 5 · 45:31
clinicalHigh-risk neuroblastoma responds well to chemotherapy due to high proliferative rate↗
▶Ep 5 · 46:00
clinicalRecent German/European publication stated that amount of local disease resection does not make a difference in outcome↗
▶Ep 5 · 46:40
quotePatients don't die of local disease. They die of systemic disease, in neuroblastoma.↗
▶Ep 5 · 46:40
clinicalPatients with high-risk neuroblastoma die of systemic metastatic disease, not local disease↗
▶Ep 5 · 53:13
clinicalNephrectomy should be avoided in neuroblastoma surgery because it requires reduction of chemotherapy doses↗
▶Ep 5 · 53:44
clinicalMonoclonal antibody against ganglioside GD2 improved two-year survival in high-risk neuroblastoma from 46% to 60%↗
▶Ep 5 · 54:40
clinicalCheckpoint inhibitors have not been successful in neuroblastoma because it is not an immunogenic tumor↗
▶Ep 5 · 54:40
quoteThe first breakthrough that we've had in any childhood cancer with immunotherapy was the antibody, the monoclonal antibody against ganglioside GD2.↗
Compiled Sandler Rapid Fire Sessions: Update Course 2015
▶Ep 4 · 0:28
quoteI congratulate you for putting on an incredible symposium↗
▶Ep 4 · 1:32
guidelineFor bilateral Wilms tumors, chemotherapy is started without biopsy and continued until tumor shrinkage stops, typically defined as less than 50% volume reduction↗
▶Ep 4 · 4:19
clinicalWhen bilateral Wilms tumors stop shrinking with chemotherapy, it is usually due to mesenchymal differentiation rather than anaplastic transformation↗
▶Ep 4 · 4:44
clinicalBilateral nephron-sparing surgery is achievable in most cases of large bilateral Wilms tumors using on-table renal hypothermia with ice and vascular clamping↗
▶Ep 4 · 5:58
quoteI never like to stick around for post-op complications. I, I'm that's a joke, sorry.↗
▶Ep 4 · 7:56
opinionMost pathologists believe anaplasia in Wilms tumor is present primarily rather than induced by chemotherapy↗
▶Ep 4 · 7:56
quoteWas, was the anaplasia there initially or secondary chemotherapy, did it differentiate into an anaplastic phenotype?↗
▶Ep 4 · 9:12
epidemiological97% of bilateral large kidney tumors in children are Wilms tumor↗
▶Ep 4 · 12:54
clinicalFor gastroschisis closure without fascial incision, umbilical hernias that develop will typically close spontaneously over 3-5 years↗
▶Ep 4 · 15:06
clinicalTegaderm dressing is left in place for approximately 3 days on gastroschisis closures, then converted to dry dressing when adherent↗
▶Ep 4 · 16:08
clinicalFeeding can be started when bowel function returns in gastroschisis cases, without waiting for complete fascial closure↗
▶Ep 4 · 19:14
clinicalIn gastroschisis with unclear atresia and inflamed bowel, reduction without anastomosis is preferred, with re-exploration at 4-6 weeks↗
▶Ep 4 · 19:26
clinicalClosing fascia in gastroschisis increases intra-abdominal pressure compared to leaving it open with Tegaderm coverage↗
▶Ep 4 · 22:07
clinicalRe-exploration at 2 weeks in complex gastroschisis can show transformation of inflamed bowel into viable intestine suitable for anastomosis↗
▶Ep 4 · 25:19
clinicalFor apple peel ileal atresia with ischemic distal bowel, resection is indicated rather than waiting for reperfusion if bowel does not pink up on the operating table↗
▶Ep 4 · 28:10
clinicalPlication of dilated proximal bowel in neonatal atresia is preferred over tapering to preserve bowel length for potential future lengthening procedures↗
Neuroblastoma
▶Ep 9 · 3:27
epidemiologicalFamilial neuroblastoma occurs in about 1% of patients↗
▶Ep 9 · 9:09
quoteThe numbers that I quote the families from that original study is that of the, I think it was 84 patients that they observed, 16 underwent resection for either growth or some other reason.↗
▶Ep 9 · 9:09
clinicalOf 84 prenatally diagnosed cases observed in the GetNucturne study, 16 (about 20%) underwent resection, with 98% event-free survival and 100% overall survival↗
▶Ep 9 · 11:03
quoteI will say the last one of these that I had at the 12-month scans, it got bigger. And we took it out and it ended up being a sequestration.↗
▶Ep 9 · 12:31
opinionFive centimeters is used as a size threshold for considering surgical resection of observed neuroblastoma↗
▶Ep 9 · 16:32
clinicalClassic findings of stage MS include high urine catecholamines, blue blebs on skin, liver metastases, and adrenal mass↗
▶Ep 9 · 23:50
clinicalOpen biopsy allows adequate tissue for NMYC amplification, ALK mutation, and ploidy studies↗
▶Ep 9 · 31:38
quoteI sort of think of it like imperforate anus. And you think of it as there's different ways of classifying imperforate anus. But for me, practically, there's high and there's low.↗
▶Ep 9 · 31:38
clinicalNMYC amplification automatically makes neuroblastoma high-risk regardless of other factors↗
▶Ep 9 · 32:40
quoteLook at NMEC amplification. It's either up, it's either amplified or it's non-amplified. And if it's amplified, it's high-risk disease, period.↗
▶Ep 9 · 35:25
guidelineAge cutoff for risk stratification is now 18 months rather than 12 months↗
▶Ep 9 · 45:31
clinicalStem cell harvesting for high-risk neuroblastoma is usually after the second cycle of chemotherapy↗
▶Ep 9 · 45:31
clinicalHigh-risk neuroblastoma responds well to chemotherapy due to high proliferative rate↗
▶Ep 9 · 46:00
clinicalRecent German/European publication stated that amount of local disease resection does not make a difference in outcome↗
▶Ep 9 · 46:40
quotePatients don't die of local disease. They die of systemic disease, in neuroblastoma.↗
▶Ep 9 · 46:40
clinicalPatients with high-risk neuroblastoma die of systemic metastatic disease, not local disease↗
▶Ep 9 · 53:13
clinicalNephrectomy should be avoided in neuroblastoma surgery because it requires reduction of chemotherapy doses↗
▶Ep 9 · 53:44
clinicalMonoclonal antibody against ganglioside GD2 improved two-year survival in high-risk neuroblastoma from 46% to 60%↗
▶Ep 9 · 54:40
clinicalCheckpoint inhibitors have not been successful in neuroblastoma because it is not an immunogenic tumor↗
▶Ep 9 · 54:40
quoteThe first breakthrough that we've had in any childhood cancer with immunotherapy was the antibody, the monoclonal antibody against ganglioside GD2.↗
