Alex Halpern

346 timestamped statements across 10 collections — auto-found in recorded discussions, each timestamp jumps to the exact moment.

Abdominal Wall Defects · guest expert Colorectal / ARM & Hirschsprung · guest expert Congenital Lung Lesions (CPAM) · guest expert Etiologies (Gastroschisis/NEC/Atresia/Volvulus) · guest expert Intestinal Rehab · guest expert Pancreatitis · episode host Pectus Excavatum · episode host Peritoneal Dialysis Access · guest expert Sarcoma (Ewing/Rhabdo) · episode host Wilms Tumor · guest expert

Featured diaries

Ep 134 · 0:41
They found that children in the high compliance group had a statistically significant decrease in rates of superficial surgical site infection when compared to children in the low compliance group, showing that standardization of perioperative care may decrease morbidity and improve outcomes in colorectal surgery.
Ep 149 · 3:14
So it seems like both of these options have their pros and cons with the intercostal nerve carablation group having a decreased total opioid use and decreased length of stay in the hospital, but increased operating room times and increased total cost.
Ep 32 · 0:51
So it seems like both of these options have their pros and cons with the intercostal nerve co ablation group having a decreased total opioid use and decreased length of stay in the hospital, but increased operating room times and increased total cost.
Ep 32 · 0:00
Thoracic epidural and intercostal nerve coagabulations are two options for pain control in patients undergoing a NUS procedure for pectus excavatum.
Ep 40 · 0:41
They concluded that there is a need for a high quality randomized controlled trials to help provide evidence-based care for these infants.
Ep 60 · 0:41
They concluded that there is a need for a high quality randomized controlled trials to help provide evidence-based care for these infants.

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Quick Literature Updates Episode 11

Ep 32 · 2:11
quote Pain control after appendectomy for perforated appendicitis can be a huge problem in kids.
Ep 32 · 2:11
quote Could Gabapentin help with pain control in these kids?
Ep 32 · 2:11
clinical Gabapentin is an anticonvulsant that is often used off label as part of multimodal pain control after major surgery.
Ep 32 · 2:11
clinical Kids who received gabapentin had a decreased postoperative length of stay after appendectomy for perforated appendicitis.
Ep 32 · 2:11
clinical Kids who received gabapentin had decreased postoperative opioid use after appendectomy for perforated appendicitis.
Ep 32 · 2:11
clinical The Children's Hospital of LA study was a retrospective cohort study looking at kids age 2 to 18 who underwent appendectomy for perforated appendicitis between 2014 and 2019.

Association of Exclusive Breast Milk Intake and Outcomes in Infants With Uncomplicated Gastroschisis: A National Cohort Study

Ep 35 · 0:00
quote Does exclusive breast milk intake affect outcomes and uncomplicated gastroschisis?
Ep 35 · 0:13
epidemiological McMaster University performed a retrospective review of infants born between 2014 and 2022 with uncomplicated gastroschisis
Ep 35 · 0:24
clinical No significant differences were found between feeding groups in rates of necrotizing enterocolitis
Ep 35 · 0:24
clinical No significant differences were found between feeding groups in duration of parenteral nutrition
Ep 35 · 0:24
clinical No significant differences were found between feeding groups in time to reach full enteral feeds
Ep 35 · 0:24
clinical Infants with exclusive breast milk intake and those with supplemental or exclusive formula intake had similar outcomes
Ep 35 · 0:24
clinical No significant differences were found between feeding groups in length of hospital stay
Ep 35 · 0:44
opinion Formula intake versus exclusive breast milk intake does not affect outcomes in uncomplicated gastroschisis
Ep 35 · 0:52
quote Does this information change your practice at all?

Use of a new vertical traction device for early traction-assisted staged closure of congenital abdominal wall defects: a prospective series of 16 patients

Ep 38 · 0:00
quote Can a novel vertical traction device help facilitate early abdominal wall closure in children with congenital abdominal wall defects?
Ep 38 · 0:14
clinical Ziegler et al. performed a prospective study in 10 patients with giant omphalocele and 6 with complicated gastroschisis
Ep 38 · 0:24
clinical The study utilized Fascia Tenses Pediatric, a traction-assisted abdominal wall closure device
Ep 38 · 0:29
clinical Complete fascial closure was achieved after a median time of 7 days in children with giant omphalocele
Ep 38 · 0:36
clinical Complete fascial closure was achieved after a median time of 5 days in children with complicated gastroschisis
Ep 38 · 0:39
clinical No patients developed abdominal compartment syndrome
Ep 38 · 0:39
clinical No ventral hernias occurred after a median follow-up of 12 months
Ep 38 · 0:46
quote So it seems like fascia tends pediatric helps facilitate early fascial closure in these patients.
Ep 38 · 0:46
opinion Fascia Tenses Pediatric helps facilitate early fascial closure in patients with congenital abdominal wall defects

Management of Gastroschisis: Timing of Delivery, Antibiotic Usage, and Closure Considerations

Ep 40 · 0:00
quote What is the optimal initial management of an infant with gastroschisis?
Ep 40 · 0:10
guideline The ABSA Outcomes and Evidence-based Practice Committee performed a systematic review on optimal initial management of infants with gastroschisis.
Ep 40 · 0:17
guideline Delivery after 37 weeks is optimal for infants with gastroschisis.
Ep 40 · 0:21
guideline Prophylactic antibiotics covering skin flora are adequate to reduce infection risk until closure in gastroschisis.
Ep 40 · 0:27
clinical Sutureless repair for gastroschisis is safe and effective.
Ep 40 · 0:27
guideline Studies support primary fascial repair for gastroschisis as long as hemodynamics and abdominal domain permit.
Ep 40 · 0:37
clinical Sutureless repair does not delay feeding or increase length of stay in gastroschisis patients.
Ep 40 · 0:41
quote They concluded that there is a need for a high quality randomized controlled trials to help provide evidence-based care for these infants.
Ep 40 · 0:41
opinion There is a need for high quality randomized controlled trials to provide evidence-based care for infants with gastroschisis.
Ep 40 · 0:50
quote Does this information change your practice at all?

Quick Literature Updates Episode 16

Ep 41 · 2:08
clinical McMaster University performed a retrospective review of infants born between 2014 and 2022 with uncomplicated gastroschisis
Ep 41 · 2:17
clinical No significant differences were found between breast milk and formula groups in length of hospital stay in uncomplicated gastroschisis
Ep 41 · 2:17
clinical Infants with exclusive breast milk intake and those with supplemental or exclusive formula intake had similar outcomes in uncomplicated gastroschisis
Ep 41 · 2:17
clinical No significant differences were found between breast milk and formula groups in duration of parenteral nutrition in uncomplicated gastroschisis
Ep 41 · 2:17
clinical No significant differences were found between breast milk and formula groups in time to reach full enteral feeds in uncomplicated gastroschisis
Ep 41 · 2:17
clinical No significant differences were found between breast milk and formula groups in rates of necrotizing enterocolitis in uncomplicated gastroschisis
Ep 41 · 2:38
quote So it seems like formula intake versus exclusive breast milk intake does not really affect outcomes in uncomplicated gastroschisis.
Ep 41 · 2:38
clinical Formula intake versus exclusive breast milk intake does not affect outcomes in uncomplicated gastroschisis

Quick Literature Updates Episode 20

Ep 43 · 1:59
epidemiological The Ziegler study included 10 patients with giant omphalocele and 6 with complicated gastroschisis
Ep 43 · 2:13
clinical Complete fascial closure was achieved after a median of 5 days in children with complicated gastroschisis using the fascia tense pediatric device
Ep 43 · 2:13
clinical Complete fascial closure was achieved after a median of 7 days in children with giant omphalocele using the fascia tense pediatric device
Ep 43 · 2:23
clinical No patients developed abdominal compartment syndrome when using the fascia tense pediatric device
Ep 43 · 2:23
clinical No ventral hernias occurred after a median follow-up of 12 months in patients treated with the fascia tense pediatric device
Ep 43 · 2:29
quote So it seems like fascia tense pediatric helps facilitate early fascial closure in these patients.

Quick Literature Updates Ep 22

Ep 44 · 2:18
guideline For gastroschisis, delivery after 37 weeks is optimal
Ep 44 · 2:21
guideline Prophylactic antibiotics covering skin flora are adequate to reduce infection risk until closure in gastroschisis
Ep 44 · 2:28
guideline Studies support primary fascial repair for gastroschisis as long as hemodynamics and abdominal domain permit
Ep 44 · 2:28
clinical Sutureless repair for gastroschisis is safe, effective, and does not delay feeding or increase length of stay
Ep 44 · 2:42
opinion There is a need for high quality randomized controlled trials to help provide evidence-based care for gastroschisis infants
Ep 44 · 2:51
quote Does this information change your practice at all?

Standardized perioperative care reduces colorectal surgical site infection in children

Ep 134 · 0:00
quote Surgical site infections are a major cause of perioperative morbidity in children undergoing colorectal surgery.
Ep 134 · 0:00
epidemiological Surgical site infections are a major cause of perioperative morbidity in children undergoing colorectal surgery
Ep 134 · 0:20
clinical The Western Pediatric Surgery Research Consortium conducted a prospective cohort study on children undergoing colorectal surgery across 10 hospitals in the US
Ep 134 · 0:32
clinical Children were split into either a high or low compliance group based on adherence to the care bundle
Ep 134 · 0:32
clinical The study utilized an 8-part perioperative care bundle
Ep 134 · 0:41
clinical Children in the high compliance group had a statistically significant decrease in rates of superficial surgical site infection when compared to children in the low compliance group
Ep 134 · 0:41
opinion Standardization of perioperative care may decrease morbidity and improve outcomes in colorectal surgery
Ep 134 · 0:41
quote They found that children in the high compliance group had a statistically significant decrease in rates of superficial surgical site infection when compared to children in the low compliance group, showing that standardization of perioperative care may decrease morbidity and improve outcomes in colorectal surgery.

Quick Literature Updates Episode 14

Ep 149 · 2:30
clinical Thoracic epidural and intercostal nerve cryoablation are two options for pain control in patients undergoing Nuss procedure for pectus excavatum
Ep 149 · 2:42
epidemiological The study was a retrospective chart review of kids who underwent Nuss procedure between 2002 and 2020
Ep 149 · 2:56
clinical The intercostal nerve cryoablation group had lower total morphine milligram equivalent requirement compared to thoracic epidural
Ep 149 · 2:56
clinical The intercostal nerve cryoablation group had shorter length of stay in the hospital compared to thoracic epidural
Ep 149 · 2:56
clinical The intercostal nerve cryoablation group had lower rates of PCA use compared to thoracic epidural
Ep 149 · 3:07
clinical The intercostal nerve cryoablation group had higher total hospitalization cost compared to thoracic epidural
Ep 149 · 3:07
clinical The intercostal nerve cryoablation group had longer operative times compared to thoracic epidural
Ep 149 · 3:14
quote So it seems like both of these options have their pros and cons with the intercostal nerve carablation group having a decreased total opioid use and decreased length of stay in the hospital, but increased operating room times and increased total cost.

Transition From Pediatric to Adult Healthcare for Colorectal Conditions: A Systematic Review

Ep 163 · 0:00
clinical Patients with anorectal malformations and Hirschsprung's disease need transfer from pediatric to adult providers to manage their colorectal conditions
Ep 163 · 0:22
epidemiological A team from Melbourne, Australia performed a systematic review and meta-analysis on transition of care for these conditions
Ep 163 · 0:28
epidemiological Eight studies were found on the topic of transition care for anorectal malformations and Hirschsprung's disease
Ep 163 · 0:30
epidemiological Little evidence exists that transfer from pediatric to adult care is happening in a coordinated or timely fashion
Ep 163 · 0:30
guideline Studies agreed that transitional care should start early in adolescence
Ep 163 · 0:40
epidemiological No models of transition care were identified in the systematic review
Ep 163 · 0:43
opinion More work is needed to ensure children with anorectal malformations and Hirschsprung's disease continue to receive optimal care as they grow older
Ep 163 · 0:53
quote Does this information change your practice at all?

Does Delayed Diagnosis of Hirschsprung Disease Impact Post-operative and Functional Outcomes? A Multi-Center Review From the Pediatric Colorectal and Pelvic Learning Consortium

Ep 165 · 0:00
quote Does delayed diagnosis of Hirschrung disease affect postoperative and functional outcomes?
Ep 165 · 0:12
clinical The Pediatric Colorectal and Pelvic Learning Consortium conducted a multi-center retrospective review from 2017 to 2023 examining the relationship between delayed diagnosis of Hirschsprung disease and postoperative/functional outcomes.
Ep 165 · 0:23
epidemiological The study included 679 patients with Hirschsprung disease from 14 different sites.
Ep 165 · 0:29
clinical Increased age at diagnosis was associated with a greater likelihood of undergoing fecal diversion after initial pull-through procedure.
Ep 165 · 0:39
clinical Increased age at diagnosis was associated with an increased risk of constipation or incontinence requiring intervention postoperatively.
Ep 165 · 0:49
clinical No association was found between age at diagnosis and need for pull-through revision.
Ep 165 · 0:49
clinical No association was found between age at diagnosis and 30-day complication rate after initial pull-through.
Ep 165 · 0:58
clinical Delayed diagnosis of Hirschsprung disease affects certain postoperative and functional outcomes in patients.
Ep 165 · 1:04
quote Does this information change your practice at all?

Quick Literature Updates Episode 17

Ep 172 · 2:05
clinical The Pediatric Colorectal and Pelvic Learning Consortium study included 679 patients with Hirschsprung disease from 14 different sites between 2017 and 2023
Ep 172 · 2:22
clinical Increased age at diagnosis of Hirschsprung disease was associated with a greater likelihood of undergoing fecal diversion after initial pull-through procedure
Ep 172 · 2:32
clinical Increasing age at diagnosis of Hirschsprung disease was associated with an increased risk of constipation or incontinence requiring intervention postoperatively
Ep 172 · 2:42
clinical No association was found between age at diagnosis of Hirschsprung disease and 30-day complication rate after initial pull-through
Ep 172 · 2:48
clinical No association was found between age at diagnosis of Hirschsprung disease and need for pull-through revision
Ep 172 · 2:51
opinion Delayed diagnosis of Hirschsprung disease does affect certain outcomes in these patients
Ep 172 · 2:51
quote So, it seems like delayed diagnosis of Hirschrung's disease does affect certain outcomes in these patients.

Quick Literature Updates Episode 18

Ep 174 · 2:21
epidemiological Eight studies were found examining transition from pediatric to adult healthcare for colorectal conditions
Ep 174 · 2:24
guideline Studies agreed that transitional care should start early in adolescence
Ep 174 · 2:24
epidemiological Little evidence exists that transfer from pediatric to adult care is happening in a coordinated or timely fashion
Ep 174 · 2:33
epidemiological No models of transition care were identified for patients with anorectal malformations and Hirschsprung's disease

Quick Literature Updates Ep 22

Ep 184 · 2:18
guideline For gastroschisis, delivery after 37 weeks is optimal
Ep 184 · 2:21
guideline Prophylactic antibiotics covering skin flora are adequate to reduce infection risk until closure in gastroschisis
Ep 184 · 2:28
guideline Studies support primary fascial repair for gastroschisis as long as hemodynamics and abdominal domain permit
Ep 184 · 2:28
clinical Sutureless repair for gastroschisis is safe, effective, and does not delay feeding or increase length of stay
Ep 184 · 2:42
opinion There is a need for high quality randomized controlled trials to help provide evidence-based care for gastroschisis infants
Ep 184 · 2:51
quote Does this information change your practice at all?

Quick Literature Updates Ep 23

Ep 185 · 2:01
clinical A working group of pediatric surgeons from Europe created 19 case scenarios with unexpected events to validate the Clavien-Madadi classification
Ep 185 · 2:10
clinical Surgeons rated scenarios based on either Clavien-Dindo classification or Clavien-Madadi classification
Ep 185 · 2:10
clinical Scenarios were circulated within the European Reference Network of inherited and congenital anomalies
Ep 185 · 2:23
epidemiological 59 surgeons completed the questionnaire
Ep 185 · 2:27
clinical The Clavien-Madadi classification showed significantly better agreement rates than Clavien-Dindo
Ep 185 · 2:27
clinical The Clavien-Madadi classification was less frequently considered inaccurate
Ep 185 · 2:34
opinion More pediatric surgeons preferred using the Clavien-Madadi classification
Ep 185 · 2:38
quote So it seems like the Clavian-Matti classification is both an accurate and useful tool in grading unexpected events in pediatric surgery.
Ep 185 · 2:38
clinical The Clavien-Madadi classification is both an accurate and useful tool in grading unexpected events in pediatric surgery

Quick Literature Updates Ep 26

Ep 188 · 2:16
clinical The ARM study used the PHIS database and included all ARM patients between 2016 and 2022
Ep 188 · 2:25
epidemiological In ARM patients, limb anomalies were diagnosed in 15.7% across all hospital encounters
Ep 188 · 2:25
epidemiological In ARM patients, cardiac anomalies were diagnosed in 77.4% across all hospital encounters
Ep 188 · 2:25
epidemiological In ARM patients, vertebral-spinal anomalies were diagnosed in 45.4% across all hospital encounters
Ep 188 · 2:25
epidemiological In ARM patients, TEF was diagnosed in 10.2% across all hospital encounters
Ep 188 · 2:25
epidemiological In ARM patients, renal anomalies were diagnosed in 39.9% across all hospital encounters
Ep 188 · 2:40
epidemiological 25.8% of female ARM patients had a congenital gynecologic malformation diagnosed
Ep 188 · 2:45
quote So it seems like the most common anomalies associated with ARMs are cardiac, vertebrospinal, renal, and gynecologic.
Ep 188 · 2:45
clinical The most common anomalies associated with ARMs are cardiac, vertebrospinal, renal, and gynecologic
Ep 188 · 2:53
guideline The authors suggest changing the VACTERL acronym to VACTERL-GS to include gynecologic and spinal conditions

Quick Literature Updates Episode 18

Ep 32 · 2:21
epidemiological Eight studies were found examining transition from pediatric to adult healthcare for colorectal conditions
Ep 32 · 2:24
epidemiological Little evidence exists that transfer from pediatric to adult care is happening in a coordinated or timely fashion
Ep 32 · 2:24
guideline Studies agreed that transitional care should start early in adolescence
Ep 32 · 2:33
epidemiological No models of transition care were identified for patients with anorectal malformations and Hirschsprung's disease

Quick Literature Updates Episode 11

Ep 52 · 2:11
clinical The Children's Hospital of LA study was a retrospective cohort study looking at kids age 2 to 18 who underwent appendectomy for perforated appendicitis between 2014 and 2019.
Ep 52 · 2:11
clinical Gabapentin is an anticonvulsant that is often used off label as part of multimodal pain control after major surgery.
Ep 52 · 2:11
clinical Kids who received gabapentin had decreased postoperative opioid use after appendectomy for perforated appendicitis.
Ep 52 · 2:11
clinical Kids who received gabapentin had a decreased postoperative length of stay after appendectomy for perforated appendicitis.
Ep 52 · 2:11
quote Pain control after appendectomy for perforated appendicitis can be a huge problem in kids.
Ep 52 · 2:11
quote Could Gabapentin help with pain control in these kids?

Association of Exclusive Breast Milk Intake and Outcomes in Infants With Uncomplicated Gastroschisis: A National Cohort Study

Ep 55 · 0:00
quote Does exclusive breast milk intake affect outcomes and uncomplicated gastroschisis?
Ep 55 · 0:13
epidemiological McMaster University performed a retrospective review of infants born between 2014 and 2022 with uncomplicated gastroschisis
Ep 55 · 0:24
clinical No significant differences were found between feeding groups in rates of necrotizing enterocolitis
Ep 55 · 0:24
clinical No significant differences were found between feeding groups in length of hospital stay
Ep 55 · 0:24
clinical No significant differences were found between feeding groups in duration of parenteral nutrition
Ep 55 · 0:24
clinical No significant differences were found between feeding groups in time to reach full enteral feeds
Ep 55 · 0:24
clinical Infants with exclusive breast milk intake and those with supplemental or exclusive formula intake had similar outcomes
Ep 55 · 0:44
opinion Formula intake versus exclusive breast milk intake does not affect outcomes in uncomplicated gastroschisis
Ep 55 · 0:52
quote Does this information change your practice at all?

Use of a new vertical traction device for early traction-assisted staged closure of congenital abdominal wall defects: a prospective series of 16 patients

Ep 58 · 0:00
quote Can a novel vertical traction device help facilitate early abdominal wall closure in children with congenital abdominal wall defects?
Ep 58 · 0:14
clinical Ziegler et al. performed a prospective study in 10 patients with giant omphalocele and 6 with complicated gastroschisis
Ep 58 · 0:24
clinical The study utilized Fascia Tenses Pediatric, a traction-assisted abdominal wall closure device
Ep 58 · 0:29
clinical Complete fascial closure was achieved after a median time of 7 days in children with giant omphalocele
Ep 58 · 0:36
clinical Complete fascial closure was achieved after a median time of 5 days in children with complicated gastroschisis
Ep 58 · 0:39
clinical No patients developed abdominal compartment syndrome
Ep 58 · 0:39
clinical No ventral hernias occurred after a median follow-up of 12 months
Ep 58 · 0:46
opinion Fascia Tenses Pediatric helps facilitate early fascial closure in patients with congenital abdominal wall defects
Ep 58 · 0:46
quote So it seems like fascia tends pediatric helps facilitate early fascial closure in these patients.

Management of Gastroschisis: Timing of Delivery, Antibiotic Usage, and Closure Considerations

Ep 60 · 0:00
quote What is the optimal initial management of an infant with gastroschisis?
Ep 60 · 0:10
guideline The ABSA Outcomes and Evidence-based Practice Committee performed a systematic review on optimal initial management of infants with gastroschisis.
Ep 60 · 0:17
guideline Delivery after 37 weeks is optimal for infants with gastroschisis.
Ep 60 · 0:21
guideline Prophylactic antibiotics covering skin flora are adequate to reduce infection risk until closure in gastroschisis.
Ep 60 · 0:27
guideline Studies support primary fascial repair for gastroschisis as long as hemodynamics and abdominal domain permit.
Ep 60 · 0:27
clinical Sutureless repair for gastroschisis is safe and effective.
Ep 60 · 0:37
clinical Sutureless repair does not delay feeding or increase length of stay in gastroschisis patients.
Ep 60 · 0:41
quote They concluded that there is a need for a high quality randomized controlled trials to help provide evidence-based care for these infants.
Ep 60 · 0:41
opinion There is a need for high quality randomized controlled trials to provide evidence-based care for infants with gastroschisis.
Ep 60 · 0:50
quote Does this information change your practice at all?

Quick Literature Updates Episode 16

Ep 61 · 2:08
clinical McMaster University performed a retrospective review of infants born between 2014 and 2022 with uncomplicated gastroschisis
Ep 61 · 2:17
clinical No significant differences were found between breast milk and formula groups in duration of parenteral nutrition in uncomplicated gastroschisis
Ep 61 · 2:17
clinical No significant differences were found between breast milk and formula groups in rates of necrotizing enterocolitis in uncomplicated gastroschisis
Ep 61 · 2:17
clinical No significant differences were found between breast milk and formula groups in time to reach full enteral feeds in uncomplicated gastroschisis
Ep 61 · 2:17
clinical No significant differences were found between breast milk and formula groups in length of hospital stay in uncomplicated gastroschisis
Ep 61 · 2:17
clinical Infants with exclusive breast milk intake and those with supplemental or exclusive formula intake had similar outcomes in uncomplicated gastroschisis
Ep 61 · 2:38
clinical Formula intake versus exclusive breast milk intake does not affect outcomes in uncomplicated gastroschisis
Ep 61 · 2:38
quote So it seems like formula intake versus exclusive breast milk intake does not really affect outcomes in uncomplicated gastroschisis.

Conservative Management of Necrotizing Enterocolitis in Newborns: Incidence and Management of Intestinal Strictures

Ep 62 · 0:00
quote How big of a problem are intestinal strictures after conservative management of necrotizing enterocolitis?
Ep 62 · 0:13
clinical The study was a retrospective review of all patients who underwent conservative management of modified Bell stage 2A or greater NEC at a single institution from 2011 to 2022.
Ep 62 · 0:27
clinical 24 of the 126 patients eventually underwent surgery for a post-NEC stricture.
Ep 62 · 0:27
epidemiological 126 patients underwent conservative management of NEC in the study period.
Ep 62 · 0:36
clinical Primary resection and anastomosis was performed in all cases of post-NEC stricture requiring surgery.
Ep 62 · 0:36
quote Primary resection and anastomosis was performed in all cases.
Ep 62 · 0:40
opinion Post-NEC strictures are a common occurrence after conservative management of NEC.
Ep 62 · 0:40
quote So, it seems like post neck strictures are a common occurrence after conservative management of neck.

Remote Ischemic Conditioning (RIC) Decreases the Incidence and Severity of Necrotizing Enterocolitis (NEC) - Validation in a Large Animal Model

Ep 64 · 0:00
clinical Remote ischemic conditioning has been shown to decrease rates of necrotizing enterocolitis in a rat model.
Ep 64 · 0:00
quote RIC, or remote ischemic conditioning, has been shown to decrease rates of necrotizing enterocolitis in a rat model.
Ep 64 · 0:16
clinical Gadal used an established piglet NEC model to test whether RIC works in a large animal model.
Ep 64 · 0:20
clinical Piglets were randomly assigned to receive RIC or serve as controls.
Ep 64 · 0:24
clinical RIC was initiated at 24 hours of life and consisted of 4 cycles of 4 minutes of arterial occlusion followed by reperfusion.
Ep 64 · 0:31
clinical Cycles were repeated every 24 hours in the low-frequency group and every 12 hours in the high-frequency group.
Ep 64 · 0:37
clinical 38 piglets were randomized into the control group, 26 into the low-frequency group, and 22 into the high-frequency group.
Ep 64 · 0:45
clinical High-frequency RIC significantly reduced the incidence of NEC when compared to controls.
Ep 64 · 0:50
clinical Low-frequency RIC did not significantly reduce the incidence of NEC.
Ep 64 · 0:53
clinical High-frequency RIC protects against NEC in a piglet model.
Ep 64 · 0:53
quote So it seems like high frequency Rick protects against neck in a piglet model.

Quick Literature Updates Ep 22

Ep 68 · 2:18
guideline For gastroschisis, delivery after 37 weeks is optimal
Ep 68 · 2:21
guideline Prophylactic antibiotics covering skin flora are adequate to reduce infection risk until closure in gastroschisis
Ep 68 · 2:28
clinical Sutureless repair for gastroschisis is safe, effective, and does not delay feeding or increase length of stay
Ep 68 · 2:28
guideline Studies support primary fascial repair for gastroschisis as long as hemodynamics and abdominal domain permit
Ep 68 · 2:42
opinion There is a need for high quality randomized controlled trials to help provide evidence-based care for gastroschisis infants
Ep 68 · 2:51
quote Does this information change your practice at all?

Quick Literature Updates Ep 27

Ep 69 · 2:05
clinical The Mina et al. study was a retrospective review of patients who underwent conservative management of modified Bell stage 2A or greater NEC from 2011 to 2022
Ep 69 · 2:20
clinical 24 of 126 conservatively managed NEC patients eventually underwent surgery for a post-NEC stricture
Ep 69 · 2:20
epidemiological 126 patients underwent conservative management of NEC in the study period
Ep 69 · 2:29
clinical Primary resection and anastomosis was performed in all post-NEC stricture cases
Ep 69 · 2:33
quote So it seems like post-neck strictures are a common occurrence after conservative management of neck.
Ep 69 · 2:33
clinical Post-NEC strictures are a common occurrence after conservative management of NEC
Intestinal Rehab 73 entries

Quick Literature Updates Episode 11

Ep 76 · 2:11
quote Could Gabapentin help with pain control in these kids?
Ep 76 · 2:11
clinical The Children's Hospital of LA study was a retrospective cohort study looking at kids age 2 to 18 who underwent appendectomy for perforated appendicitis between 2014 and 2019.
Ep 76 · 2:11
clinical Gabapentin is an anticonvulsant that is often used off label as part of multimodal pain control after major surgery.
Ep 76 · 2:11
clinical Kids who received gabapentin had decreased postoperative opioid use after appendectomy for perforated appendicitis.
Ep 76 · 2:11
clinical Kids who received gabapentin had a decreased postoperative length of stay after appendectomy for perforated appendicitis.
Ep 76 · 2:11
quote Pain control after appendectomy for perforated appendicitis can be a huge problem in kids.

Association of Exclusive Breast Milk Intake and Outcomes in Infants With Uncomplicated Gastroschisis: A National Cohort Study

Ep 84 · 0:00
quote Does exclusive breast milk intake affect outcomes and uncomplicated gastroschisis?
Ep 84 · 0:13
epidemiological McMaster University performed a retrospective review of infants born between 2014 and 2022 with uncomplicated gastroschisis
Ep 84 · 0:24
clinical Infants with exclusive breast milk intake and those with supplemental or exclusive formula intake had similar outcomes
Ep 84 · 0:24
clinical No significant differences were found between feeding groups in time to reach full enteral feeds
Ep 84 · 0:24
clinical No significant differences were found between feeding groups in duration of parenteral nutrition
Ep 84 · 0:24
clinical No significant differences were found between feeding groups in rates of necrotizing enterocolitis
Ep 84 · 0:24
clinical No significant differences were found between feeding groups in length of hospital stay
Ep 84 · 0:44
opinion Formula intake versus exclusive breast milk intake does not affect outcomes in uncomplicated gastroschisis
Ep 84 · 0:52
quote Does this information change your practice at all?

Use of a new vertical traction device for early traction-assisted staged closure of congenital abdominal wall defects: a prospective series of 16 patients

Ep 87 · 0:00
quote Can a novel vertical traction device help facilitate early abdominal wall closure in children with congenital abdominal wall defects?
Ep 87 · 0:14
clinical Ziegler et al. performed a prospective study in 10 patients with giant omphalocele and 6 with complicated gastroschisis
Ep 87 · 0:24
clinical The study utilized Fascia Tenses Pediatric, a traction-assisted abdominal wall closure device
Ep 87 · 0:29
clinical Complete fascial closure was achieved after a median time of 7 days in children with giant omphalocele
Ep 87 · 0:36
clinical Complete fascial closure was achieved after a median time of 5 days in children with complicated gastroschisis
Ep 87 · 0:39
clinical No patients developed abdominal compartment syndrome
Ep 87 · 0:39
clinical No ventral hernias occurred after a median follow-up of 12 months
Ep 87 · 0:46
opinion Fascia Tenses Pediatric helps facilitate early fascial closure in patients with congenital abdominal wall defects
Ep 87 · 0:46
quote So it seems like fascia tends pediatric helps facilitate early fascial closure in these patients.

Management of Gastroschisis: Timing of Delivery, Antibiotic Usage, and Closure Considerations

Ep 90 · 0:00
quote What is the optimal initial management of an infant with gastroschisis?
Ep 90 · 0:10
guideline The ABSA Outcomes and Evidence-based Practice Committee performed a systematic review on optimal initial management of infants with gastroschisis.
Ep 90 · 0:17
guideline Delivery after 37 weeks is optimal for infants with gastroschisis.
Ep 90 · 0:21
guideline Prophylactic antibiotics covering skin flora are adequate to reduce infection risk until closure in gastroschisis.
Ep 90 · 0:27
guideline Studies support primary fascial repair for gastroschisis as long as hemodynamics and abdominal domain permit.
Ep 90 · 0:27
clinical Sutureless repair for gastroschisis is safe and effective.
Ep 90 · 0:37
clinical Sutureless repair does not delay feeding or increase length of stay in gastroschisis patients.
Ep 90 · 0:41
opinion There is a need for high quality randomized controlled trials to provide evidence-based care for infants with gastroschisis.
Ep 90 · 0:41
quote They concluded that there is a need for a high quality randomized controlled trials to help provide evidence-based care for these infants.
Ep 90 · 0:50
quote Does this information change your practice at all?

Quick Literature Updates Episode 16

Ep 91 · 2:08
clinical McMaster University performed a retrospective review of infants born between 2014 and 2022 with uncomplicated gastroschisis
Ep 91 · 2:17
clinical No significant differences were found between breast milk and formula groups in time to reach full enteral feeds in uncomplicated gastroschisis
Ep 91 · 2:17
clinical Infants with exclusive breast milk intake and those with supplemental or exclusive formula intake had similar outcomes in uncomplicated gastroschisis
Ep 91 · 2:17
clinical No significant differences were found between breast milk and formula groups in length of hospital stay in uncomplicated gastroschisis
Ep 91 · 2:17
clinical No significant differences were found between breast milk and formula groups in duration of parenteral nutrition in uncomplicated gastroschisis
Ep 91 · 2:17
clinical No significant differences were found between breast milk and formula groups in rates of necrotizing enterocolitis in uncomplicated gastroschisis
Ep 91 · 2:38
clinical Formula intake versus exclusive breast milk intake does not affect outcomes in uncomplicated gastroschisis
Ep 91 · 2:38
quote So it seems like formula intake versus exclusive breast milk intake does not really affect outcomes in uncomplicated gastroschisis.

Conservative Management of Necrotizing Enterocolitis in Newborns: Incidence and Management of Intestinal Strictures

Ep 92 · 0:00
quote How big of a problem are intestinal strictures after conservative management of necrotizing enterocolitis?
Ep 92 · 0:13
clinical The study was a retrospective review of all patients who underwent conservative management of modified Bell stage 2A or greater NEC at a single institution from 2011 to 2022.
Ep 92 · 0:27
epidemiological 126 patients underwent conservative management of NEC in the study period.
Ep 92 · 0:27
clinical 24 of the 126 patients eventually underwent surgery for a post-NEC stricture.
Ep 92 · 0:36
clinical Primary resection and anastomosis was performed in all cases of post-NEC stricture requiring surgery.
Ep 92 · 0:36
quote Primary resection and anastomosis was performed in all cases.
Ep 92 · 0:40
opinion Post-NEC strictures are a common occurrence after conservative management of NEC.
Ep 92 · 0:40
quote So, it seems like post neck strictures are a common occurrence after conservative management of neck.

Remote Ischemic Conditioning (RIC) Decreases the Incidence and Severity of Necrotizing Enterocolitis (NEC) - Validation in a Large Animal Model

Ep 95 · 0:00
quote RIC, or remote ischemic conditioning, has been shown to decrease rates of necrotizing enterocolitis in a rat model.
Ep 95 · 0:00
clinical Remote ischemic conditioning has been shown to decrease rates of necrotizing enterocolitis in a rat model.
Ep 95 · 0:16
clinical Gadal used an established piglet NEC model to test whether RIC works in a large animal model.
Ep 95 · 0:20
clinical Piglets were randomly assigned to receive RIC or serve as controls.
Ep 95 · 0:24
clinical RIC was initiated at 24 hours of life and consisted of 4 cycles of 4 minutes of arterial occlusion followed by reperfusion.
Ep 95 · 0:31
clinical Cycles were repeated every 24 hours in the low-frequency group and every 12 hours in the high-frequency group.
Ep 95 · 0:37
clinical 38 piglets were randomized into the control group, 26 into the low-frequency group, and 22 into the high-frequency group.
Ep 95 · 0:45
clinical High-frequency RIC significantly reduced the incidence of NEC when compared to controls.
Ep 95 · 0:50
clinical Low-frequency RIC did not significantly reduce the incidence of NEC.
Ep 95 · 0:53
quote So it seems like high frequency Rick protects against neck in a piglet model.
Ep 95 · 0:53
clinical High-frequency RIC protects against NEC in a piglet model.

Quick Literature Updates Ep 22

Ep 99 · 2:18
guideline For gastroschisis, delivery after 37 weeks is optimal
Ep 99 · 2:21
guideline Prophylactic antibiotics covering skin flora are adequate to reduce infection risk until closure in gastroschisis
Ep 99 · 2:28
guideline Studies support primary fascial repair for gastroschisis as long as hemodynamics and abdominal domain permit
Ep 99 · 2:28
clinical Sutureless repair for gastroschisis is safe, effective, and does not delay feeding or increase length of stay
Ep 99 · 2:42
opinion There is a need for high quality randomized controlled trials to help provide evidence-based care for gastroschisis infants
Ep 99 · 2:51
quote Does this information change your practice at all?

Quick Literature Updates Ep 27

Ep 100 · 2:05
clinical The Mina et al. study was a retrospective review of patients who underwent conservative management of modified Bell stage 2A or greater NEC from 2011 to 2022
Ep 100 · 2:20
clinical 24 of 126 conservatively managed NEC patients eventually underwent surgery for a post-NEC stricture
Ep 100 · 2:20
epidemiological 126 patients underwent conservative management of NEC in the study period
Ep 100 · 2:29
clinical Primary resection and anastomosis was performed in all post-NEC stricture cases
Ep 100 · 2:33
quote So it seems like post-neck strictures are a common occurrence after conservative management of neck.
Ep 100 · 2:33
clinical Post-NEC strictures are a common occurrence after conservative management of NEC
Pancreatitis 9 entries

Multi-Institutional Analysis of Choledocholithiasis in Pediatric vs Adult Patients

Ep 22 · 0:00
quote Can a surgery first approach be used for the management of cholodocholithiasis in children?
Ep 22 · 0:11
epidemiological Dantes et al. performed a multi-center retrospective review of pediatric and adult patients treated for choledocholithiasis between 2018 and 2024
Ep 22 · 0:22
epidemiological 724 patients were included in the study
Ep 22 · 0:25
clinical Surgery first approach with upfront laparoscopic cholecystectomy with intraoperative cholangiogram was performed in 201 pediatric patients and 169 adult patients
Ep 22 · 0:35
clinical Laparoscopic common bile duct exploration was attempted in 84 children and 140 adults in the surgery first group
Ep 22 · 0:43
clinical Common bile duct exploration success was higher in pediatric than adult patients
Ep 22 · 0:43
clinical Complication rates were similar between pediatric and adult patients in the surgery first approach
Ep 22 · 0:49
opinion A surgery first approach can be a safe and effective tool for managing choledocholithiasis in pediatric patients
Ep 22 · 0:55
quote Does this information change your practice?
Pectus Excavatum 26 entries

Cost and outcomes of intercostal nerve cryoablation versus thoracic epidural following the Nuss procedure

Ep 32 · 0:00
clinical Thoracic epidural and intercostal nerve cryoablation are two options for pain control in patients undergoing a Nuss procedure for pectus excavatum
Ep 32 · 0:00
quote Thoracic epidural and intercostal nerve coagabulations are two options for pain control in patients undergoing a NUS procedure for pectus excavatum.
Ep 32 · 0:19
clinical Dr. Tsai and his team from Penn State conducted a retrospective chart review looking at kids who underwent a Nuss procedure between 2002 and 2020
Ep 32 · 0:21
clinical The intercostal nerve cryoablation group had lower rates of PCA use compared to thoracic epidural
Ep 32 · 0:21
clinical The intercostal nerve cryoablation group had lower total morphine milligram equivalent requirement compared to thoracic epidural
Ep 32 · 0:21
clinical The intercostal nerve cryoablation group had shorter length of stay in the hospital compared to thoracic epidural
Ep 32 · 0:44
clinical The intercostal nerve cryoablation group had longer operative times compared to thoracic epidural
Ep 32 · 0:44
clinical The intercostal nerve cryoablation group had higher total hospitalization cost than the thoracic epidural group
Ep 32 · 0:51
quote So it seems like both of these options have their pros and cons with the intercostal nerve co ablation group having a decreased total opioid use and decreased length of stay in the hospital, but increased operating room times and increased total cost.
Ep 32 · 0:51
opinion Both intercostal nerve cryoablation and thoracic epidural have pros and cons for pain control following Nuss procedure

Quick Literature Updates Episode 13

Ep 37 · 2:32
epidemiological The meta-analysis included 5 studies on early peritoneal dialysis after pediatric cardiac surgery
Ep 37 · 2:35
clinical Early initiation of peritoneal dialysis was associated with decreased post-operative mortality in infants after cardiac surgery
Ep 37 · 2:41
clinical Early initiation of peritoneal dialysis shortened length of stay in the ICU after pediatric cardiac surgery
Ep 37 · 2:41
clinical Early initiation of peritoneal dialysis shortened duration of mechanical ventilation after pediatric cardiac surgery
Ep 37 · 2:49
quote So it seems that early initiation of peritoneal dialysis may benefit infants after pediatric cardiac surgery.

Vacuum Bell Therapy for Pectus Excavatum: Long-term Experience at a Single Center

Ep 48 · 0:00
quote What factors affect outcomes in patients with pectus excavatum treated with vacuum valve therapy?
Ep 48 · 0:13
clinical The study was a single institution retrospective chart review conducted from 2012 to 2023
Ep 48 · 0:20
epidemiological 278 patients were included in the analysis
Ep 48 · 0:23
clinical 31 patients had excellent corrections with vacuum bell therapy
Ep 48 · 0:23
clinical 247 patients had non-excellent corrections with vacuum bell therapy
Ep 48 · 0:29
clinical Initial chest depth less than 1.5 centimeters is a predictor of positive outcomes
Ep 48 · 0:29
clinical Chest wall flexibility is a predictor of positive outcomes
Ep 48 · 0:29
clinical Excellent correction was more common in children 8 to 12.9 years old
Ep 48 · 0:41
clinical Improved outcomes are seen in younger patients with more mild defects and greater chest wall flexibility
Ep 48 · 0:41
opinion Excellent correction in children with pectus excavatum treated with vacuum bell therapy is uncommon
Ep 48 · 0:54
quote Does this information change your practice?

Early Peritoneal Dialysis and Postoperative Outcomes in Infants After Pediatric Cardiac Surgery

Ep 6 · 0:00
quote Can early initiation of peritoneal dialysis after pediatric cardiac surgery improve outcomes?
Ep 6 · 0:14
clinical Dr. Dudike and his team performed a systematic review and meta-analysis on early peritoneal dialysis after pediatric cardiac surgery
Ep 6 · 0:19
clinical Five studies were included in the meta-analysis
Ep 6 · 0:24
clinical Early initiation of peritoneal dialysis was associated with decreased postoperative mortality
Ep 6 · 0:30
clinical Early initiation of peritoneal dialysis shortened duration of mechanical ventilation
Ep 6 · 0:30
clinical Early initiation of peritoneal dialysis shortened length of stay in the ICU
Ep 6 · 0:30
opinion Early initiation of peritoneal dialysis may benefit infants after pediatric cardiac surgery

Quick Literature Updates Episode 13

Ep 7 · 2:32
epidemiological The meta-analysis included 5 studies on early peritoneal dialysis after pediatric cardiac surgery
Ep 7 · 2:35
clinical Early initiation of peritoneal dialysis was associated with decreased post-operative mortality in infants after cardiac surgery
Ep 7 · 2:41
clinical Early initiation of peritoneal dialysis shortened duration of mechanical ventilation after pediatric cardiac surgery
Ep 7 · 2:41
clinical Early initiation of peritoneal dialysis shortened length of stay in the ICU after pediatric cardiac surgery
Ep 7 · 2:49
quote So it seems that early initiation of peritoneal dialysis may benefit infants after pediatric cardiac surgery.

Female Fertility Cryopreservation Outcomes in Childhood Cancer: A Systematic Review

Ep 27 · 0:00
quote What does the current literature say about outcomes of female fertility cryopreservation in children with cancer?
Ep 27 · 0:13
clinical Gillippelli et al. performed a systematic retrospective review of female fertility cryopreservation outcomes in children with cancer
Ep 27 · 0:19
clinical 12 studies were included in the final systematic review
Ep 27 · 0:19
clinical The review initially examined 104 abstracts and 34 full text articles
Ep 27 · 0:27
epidemiological 5.9% of patients who underwent ovarian tissue cryopreservation later received ovarian tissue transplantation
Ep 27 · 0:27
epidemiological Ovarian tissue cryopreservation was performed in 501 patients across the included studies
Ep 27 · 0:38
clinical 33% of patients who underwent ovarian tissue transplantation were able to become pregnant
Ep 27 · 0:44
opinion Ovarian tissue cryopreservation has great advantages for pediatric cancer patients but needs to be studied further
Ep 27 · 0:44
quote So, it seems like ovarian tissue cryopreservation has great advantages for pediatric cancer patients, but needs to be studied further.
Ep 27 · 0:52
quote Does this information change your practice at all?

Same-Day Discharge for Elective Pediatric Laparoscopic Gastrostomy Tube Insertion is Safe and Increasing in Frequency; A NSQIP Pediatric Retrospective Review 2017 to 2021

Ep 29 · 0:00
quote What are the trends and outcomes of same-day discharge after pediatric elective laparoscopic gastrostomy?
Ep 29 · 0:13
clinical The study analyzed the ACS NSQIP Pediatric database from 2017 to 2021
Ep 29 · 0:21
epidemiological 5,947 pediatric patients underwent elective laparoscopic gastrostomy tube placement in the study period
Ep 29 · 0:29
epidemiological 4.7% of patients were discharged the same day after laparoscopic gastrostomy tube placement
Ep 29 · 0:33
clinical There were no significant differences in any other complications between same-day discharge and 1-2 day discharge patients
Ep 29 · 0:33
clinical There were no significant differences in 30-day unplanned readmissions between same-day discharge and 1-2 day discharge patients
Ep 29 · 0:33
clinical There were no significant differences in reoperations between same-day discharge and 1-2 day discharge patients
Ep 29 · 0:46
epidemiological Same-day discharge after pediatric laparoscopic gastrostomy is not commonly done
Ep 29 · 0:46
quote So, it seems like same day discharge for pediatric patients after elective laparoscopic gastrostomy is safe, but not commonly done.
Ep 29 · 0:46
opinion Same-day discharge for pediatric patients after elective laparoscopic gastrostomy appears to be safe
Wilms Tumor 6 entries

Quick Literature Updates Ep 21

Ep 16 · 2:08
epidemiological The systematic review initially reviewed 104 abstracts and 34 full text articles, ultimately including 12 studies
Ep 16 · 2:16
epidemiological 5.9% of patients who underwent ovarian tissue cryopreservation subsequently underwent ovarian tissue transplantation
Ep 16 · 2:16
epidemiological Ovarian tissue cryopreservation was performed in 501 patients
Ep 16 · 2:27
quote After ovarian tissue transplantation, 33% of these patients were able to become pregnant.
Ep 16 · 2:27
clinical 33% of patients who underwent ovarian tissue transplantation were able to become pregnant
Ep 16 · 2:33
opinion Ovarian tissue cryopreservation has advantages for pediatric cancer patients but needs further study