Gastroesophageal Reflux Disease
The vast majority of kids who have vomiting, respiratory symptoms, and wheezing are more likely to have oropharyngeal dysphagia and aspiration during swallowing than gastroesophageal reflux
clinicalRachel Rosen3:23 ↗
The peak age of reflux is between 4 and 6 months of age
epidemiologicalRachel Rosen4:32 ↗
Proton pump inhibitors are not beneficial in children under the age of 1 because these kids reflux non-acidic gastric content (milk)
clinicalRachel Rosen5:26 ↗
Normal gastric emptying of infants means they still have milk in their stomach for up to 2 to 3 hours; acid production only starts after the 3 hour mark
clinicalRachel Rosen5:45 ↗
Studies have shown both with H2 blockers and PPIs you can get sepsis, UTIs, necrotizing enterocolitis, pneumonias, pharyngitis, upper respiratory infections, and C. diff in young infants
clinicalRachel Rosen7:21 ↗
In kids under the age of 5 presenting with respiratory symptoms, eosinophilic esophagitis is found in about 10% when endoscopy is performed
epidemiologicalRachel Rosen9:53 ↗
The number one presentation of eosinophilic esophagitis in kids under age 5 is chronic cough, followed by vomiting or failure to thrive
clinicalRachel Rosen9:41 ↗
You really need to scope every kid before they would get a Nissen because you don't want to wrap a kid who has eosinophilic esophagitis
guidelineRachel Rosen10:54 ↗
The most likely allergen in eosinophilic esophagitis is dairy in about 60 to 70% of kids
epidemiologicalRachel Rosen11:57 ↗
Macrolides like erythromycin are motilin agonists that make the antrum contract and help with vomiting, plus have anti-inflammatory benefits for the airway and lungs
clinicalRachel Rosen16:28 ↗
There are no great normal values for the number of reflux episodes in pediatric patients, making pH impedance interpretation difficult
clinicalRachel Rosen17:48 ↗
Reflux is rarely a cause of failure to thrive and respiratory symptoms in infants, especially at 6 months of age when reflux should be improving as solid food is introduced
opinionRachel Rosen19:18 ↗
An upper GI is not a good study for reflux diagnosis; it only helps identify anatomical problems in about 4% of patients
clinicalWhit Holcomb22:38 ↗
The majority of kids with oropharyngeal dysphagia will outgrow it by 3 to 4 months of age
clinicalRachel Rosen28:21 ↗
About 75% of NICU patients with dysphagia managed with NG tubes will not need to go on to gastrostomy
epidemiologicalRachel Rosen28:42 ↗
When gastrostomy goes in for children who aspirate from oropharyngeal dysphagia, their rates of hospitalization are about 15 times higher than if you just fed them by mouth
epidemiologicalRachel Rosen29:37 ↗
Nasogastric tubes in neonates under 3 months of age don't come out that frequently
clinicalRachel Rosen31:13 ↗
If symptoms go away with nasojejunal feeds, reflux likely is playing a role and Nissen may be an option
clinicalRachel Rosen34:09 ↗
Kids who wretch preoperatively are the most miserable post-Nissen because they wretch a lot postoperatively too
clinicalRachel Rosen35:20 ↗
Rome IV criteria define three categories: non-erosive reflux disease (NERD) with abnormal acid burden, reflux hypersensitivity with normal acid but symptom correlation, and functional heartburn with no correlation
guidelineRachel Rosen40:54 ↗
New GERD guidelines recommend treating with PPI for 2 months then attempting to wean, with goal of weaning ideally 2 times per year
guidelineRachel Rosen44:04 ↗
If you have reflux beyond the age of 3 or 4, you're likely to continue to have it long term
clinicalRachel Rosen45:31 ↗
In a prospective randomized trial of 107 patients using minimal mobilization technique, neither group required a redo fundoplication for transmigration
clinicalWhit Holcomb46:40 ↗
The primary reason for redo fundoplication historically was transmigration of the wrap into the chest
epidemiologicalWhit Holcomb47:08 ↗
By doing minimal mobilization and placing sutures between esophagus and crura, transmigration rate was reduced from 12% to 5%
clinicalWhit Holcomb57:32 ↗
With minimal mobilization alone (no sutures), there was zero transmigration in prospective trial, with only one wrap loosening
clinicalWhit Holcomb58:23 ↗
Kids who aspirate during swallowing and then get a Nissen have saliva pool in their esophagus over the Nissen, leading to gagging, wretching, and coughing
clinicalRachel Rosen49:02 ↗
Blenderized feeds using table food migrate to the antrum away from the LES and cardia, reducing reflux symptoms in neurologically impaired children
clinicalRachel Rosen52:39 ↗
Pyloric Botox works not only for delayed emptying but also with the sensory component that triggers wretching
clinicalRachel Rosen54:19 ↗
Botox doesn't reliably improve gastric emptying but helps significantly with wretching, possibly by affecting sensory mechanisms
clinicalRachel Rosen68:18 ↗