Exploring Organ-Specific Extracellular Vesicles in Metabolic Improvements Following Bariatric Surgery in Youth With Obesity
Expert / Speaker
Exploring Organ
General Surgery
Timestops
0:00
Bariatric Surgery Basics
Introduction to bariatric surgery and its effects on organs
0:07
Small Etchocelio Vesicles Explained
Small vesicles released by organs, their role in crosstalk after surgery
0:16
Liver Signals After Surgery
Decrease in liver signals and mRNA in small vesicles after bariatric surgery
0:24
Antiposterrized Cargo in Vesicles
Remain unchanged in vesicle cargo despite changes in liver signals
0:34
Correlation with BMI and Weight Loss
Strong correlation between liver-derived vesicle signals and weight loss outcomes
0:44
Crosstalk Between Liver and Fat Tissue
New understanding of crosstalk driving metabolic improvements after surgery
0:55
Metabolic Improvements After Surgery
Clinical benefits of bariatric surgery in youth with obesity
Topic overview
Ahlee Kim, Tsuyoshi Okura, Kwangmin Choi, Rupinder Gill, Vishnupriya J Borra, Kazutoshi Murakami, Andrew Poulos, Xiang Zhang, Todd Jenkins, Amy Sanghavi Shah, Michael Helmrath, Takahisa Nakamura
Objective: Vertical sleeve gastrectomy (VSG) promotes significant metabolic improvements, though the underlying molecular mechanisms are not fully understood. Emerging evidence suggests that small extracellular vesicles (sEVs) contribute to metabolic improvements post VSG, such as improved fatty liver disease or adipose tissue function; however, it is unclear how different organ-specific sEVs interact with various metabolic parameters. The objective of this study is to establish the role of organ-specific sEVs in the metabolic improvements post VSG.
Methods: Demographic and anthropometric data, metabolic parameters, and sEV samples were collected pre VSG and 3-6 months post VSG in youth with obesity. sEV RNA was sequenced for bioinformatics analyses.
Results: A significant reduction of the liver-enriched mRNA cargo in sEVs was observed post VSG, whereas adipose-enriched mRNA cargo showed no such reduction. Liver-enriched mRNA cargo correlated with BMI, leptin, and resistin 6 months post VSG. Analysis of delta values (post minus pre surgery) revealed that adipose-enriched mRNA cargo correlated with markers of liver damage, whereas liver-derived mRNA cargo correlated with branched-chain amino acids.
Conclusions: Following VSG, significant changes occur in the liver-enriched mRNA cargo of sEVs. Liver-derived sEVs appear to influence adipose metabolism, whereas adipose-derived sEVs are linked with liver function, suggesting dynamic intertissue cross talk that shapes systemic metabolic outcomes.
Intended audience: Healthcare professionals and clinicians.
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Specialty
Disease/Condition
Anatomy/Organ System
Procedure/Intervention
Care Context
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Transcript
Speaker: Exploring Organ
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