Liver Tumors (Hepatoblastoma/HCC)
Also covered as: hepatoblastoma · hepatocellular carcinoma · metastatic hepatoblastoma · pulmonary metastases · tyrosinemia · neuroblastoma · mesenchymal hamartoma · bronchopulmonary dysplasia
Educational content from recorded physician discussions — not medical advice. Always talk to your child's care team about your child's situation.
Answers come only from this collection's statement ledger and cite the exact moment · not medical advice
Content of this collection
Foundations
3 items
Hepatoblastoma with Dr. Greg Tiao
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Hepatoblastoma is the most common malignant liver tumor in the pediatric population but treatment strategies have changed dramatically over the past couple of decades so today we will review the basics of hepatoblastoma with Dr. Greg Tiao,
podcast · 10:12 · Feb 2022
Hepatoblastoma with Dr. Greg Tiao
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Hepatoblastoma is the most common malignant liver tumor in the pediatric population. But treatment strategies have changed dramatically over the past 25 years. That’s why today, were going to review the basics-with an expert.
00:27:38-0027:
video · Mar 2022
Pediatric Obesity Is a Disease: Treatment, Medications, Surgery & Equity in Care with Dr. Justin Ryder
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In this segment from Lurie Children’s Hospital, Dr. Justin Ryder breaks down the evolving science and treatment paradigm of pediatric obesity—highlighting why it must be approached as a chronic, biologically driven disease rather than a lif
video · 6:48 · Mar 2026
Medical Management
1 item
Retreatment with Cisplatin May Provide a Survival Advantage for Children with Relapsed/Refractory Hepatoblastoma: An Institutional Experience
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Katherine M Somers, Rachel Bernstein Tabbouche, Alexander Bondoc, Alexander J Towbin, Sarangarajan Ranganathan, Greg Tiao, James I GellerBackground: Hepatoblastoma (HB) is the most common liver malignancy in children. There is no standard o
video · 1:10 · Jan 2026
Surgical Management
2 items
Indocyanine green is a sensitive adjunct in the identification and surgical management of local and metastatic hepatoblastoma
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Charissa M Lake, Alexander J Bondoc, Roshni Dasgupta, Todd M Jenkins, Alexander J Towbin, Ethan A Smith, Maria H Alonso, James I Geller, Gregory M TiaoBackground: Hepatoblastoma is the most common primary pediatric liver malignancy. Indocya
video · 1:04 · Jan 2026
Characteristics of Transfusion and Association With Oncologic Outcomes in Hepatoblastoma Resection
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Stephanie F Polites, Jennifer H Aldrink, Timothy B Lautz, Robert A Vierkant, Mecklin V Ragan, Audra Reiter, Stephanie Y Chen, Eugene S Kim, Hannah N Rinehardt, Marcus M Malek, Andrew M Fleming, Andrew J Murphy, Jonathan P Roach, Sridharan R
video · 1:10 · Apr 2026
Evidence & Research
6 items
Journal of Pediatric Surgery Article Review: June 2022, AAP Issue
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Here's the June 2022 issue of JPS article highlights. This time we're talking to Dr. Nicole Chandler and authors Drs. Elizabeth Beierle, Marcus Malek, Biren Modi, Amelia Collings and Katherine Flynn O'Brien.
Hosts: Ellen Encisco, Em Tomb
video · 15:54 · Sep 2022
Journal of Pediatric Surgery Article Review: June 2022, AAP Issue
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Here's the June 2022 issue of JPS article highlights. This time we're talking to Dr. Nicole Chandler and authors Drs. Elizabeth Beierle, Marcus Malek, Biren Modi, Amelia Collings and Katherine Flynn O'Brien.
Hosts: Ellen Encisco, Em Tomb
podcast · 15:54 · Sep 2022
BOB Ped Surg 2023 - Andrew Fleming, AAP - Presentation
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Watch Andrew Fleming, MD, present his presentation on "Aggressive Pursuit of No Evidence of Disease Status in Hepatoblastoma Improves Survival."
video · Feb 2023
Aggressive Pursuit of No Evidence of Disease Status in Hepatoblastoma Improves Survival
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Another article you should know abou by Cecilia Gigena
“Aggressive Pursuit of No Evidence of Disease Status in Hepatoblastoma Improves Survival: An observational study” Fleming A et.al.
Authors: Andrew M. Fleming, Andrew J. Murphy, Su
video · Jun 2023
Journal of Pediatric Article Review: June 2023, AAP Issue
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We’re featuring Journal of Pediatric surgery articles to bring you some of the latest news!
This week we are discussing June 2023 articles from the AAP issue, with editor Dr. Colin A. Martin and authors Drs. Brad Warner and Andrew Flemin
podcast · 13:57 · Sep 2023
Social Determinants of Health Influence on Survival in Wilms Tumor, Neuroblastoma, and Hepatoblastoma
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Colleen P Nofi, Bailey K Roberts, Erin G Brown, Barrie S Rich, Meera Kotagal, & Richard D Glick Background: The influence of social determinants of health (SDOH) on childhood cancer outcomes is complex and understudied. This study aimed to
video · 1:06 · Jan 2026
Case-Based Learning
1 item
Clinical & Research Update: Pediatric Liver Tumors - A Case-Based Discussion with Drs. Katherine Somers & Alex Bondoc
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This live event offered a focused, case-based conversation exploring current approaches to pediatric liver tumors across four critical domains:• Liver transplantation — indications, timing, and outcomes• Relapse management — surveillance an
video · 69:23 · Apr 2026
In-Depth Reviews
3 items
Hepatoblastoma: Update Course 2014
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Dr. Matthew Clifton gives a presentation on hepatoblastoma including discussion of pre-treatment extent of disease (pretext) and post-treatment extent of disease staging for hepatoblastoma, management and surgical resection based on stages,
video · 24:43 · Nov 2018
Hepatoblastoma: Update Course 2014
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During the 2nd Annual Stay Current in Pediatric Surgery Update Course in 2014,Dr. Matthew Clifton presents on hepatoblastoma.Topics discussed includepre-treatment extent of disease (pretext) and post-treatment extent of disease staging for
video · Jan 2019
Hepatoblastoma
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This is an interactive discussion between Todd Ponsky, MD and Max Langham, MD on the management of hepatoblastomas. Dr. Max Langham is a Professor of Surgery and Pediatrics and the Vice Chairman of the Department of Surgery at the Universi
podcast · 54:16 · Dec 2020
Long-Term Care
1 item
Quality of Life Outcomes for Patients Who Underwent Conventional Resection and Liver Transplantation for Locally Advanced Hepatoblastoma
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Zishaan Farooqui, Michael Johnston, Emily Schepers, Nathalie Brewer, Stephen Hartman, Todd Jenkins, Alexander Bondoc, Ahna Pai, James Geller, Gregory M TiaoAbstract:Hepatoblastoma is the most common malignant liver tumor of childhood, with
video · 1:05 · Jan 2026
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Every statement below comes from the recorded discussions, with its speaker and moment.
Retreatment with Cisplatin May Provide a Survival Advantage for Children with Relapsed/Refractory Hepatoblastoma: An Institutional Experience
There is no established standard salvage therapy regimen for relapsed hepatoblastoma
guidelineSophia Schermerhorn0:12 ↗
The Cincinnati Children's retrospective review of 30 patients represents one of the largest published cohorts evaluating patients with refractory or recurrent hepatoblastoma
epidemiologicalSophia Schermerhorn0:17 ↗
The overall survival for the cohort was about 50%
clinicalSophia Schermerhorn0:25 ↗
Children who received cisplatin as part of their salvage therapy had survival of about 80% compared to 25% for those who did not receive cisplatin
clinicalSophia Schermerhorn0:28 ↗
The improved survival outcomes with cisplatin may be due to persistent platinum sensitivity or better tumor biology rather than proving causality
opinionSophia Schermerhorn0:36 ↗
Most patients underwent additional surgery as part of their salvage therapy, either liver resection, liver transplant, or pulmonary metastasectomy
clinicalSophia Schermerhorn0:49 ↗
Salvage therapy for relapsed hepatoblastoma is multimodal
clinicalSophia Schermerhorn0:57 ↗
Cisplatin retreatment should be balanced with the risk of cumulative toxicity
opinionSophia Schermerhorn0:59 ↗
Indocyanine green is a sensitive adjunct in the identification and surgical management of local and metastatic hepatoblastoma
This is a single institution retrospective review of patients who received ICG prior to either pulmonary metastatectomy or liver resection for hepatoblastoma
clinicalSophia Schermerhorn0:12 ↗
ICG was highly sensitive for detecting hepatoblastoma, about 90%
clinicalSophia Schermerhorn0:22 ↗
In a meaningful number of cases, ICG was able to detect tumor deposits that were not visible, palpable, or detectable on preoperative imaging
clinicalSophia Schermerhorn0:27 ↗
Specificity was lower than sensitivity with false positives
clinicalSophia Schermerhorn0:39 ↗
False positives often represented vascular changes or inflammation
clinicalSophia Schermerhorn0:43 ↗
There were no adverse outcomes associated with any of the additional resections guided by ICG
clinicalSophia Schermerhorn0:46 ↗
ICG was effective in both open and minimally invasive surgery
clinicalSophia Schermerhorn0:50 ↗
ICG was effective in both relapse and primary disease
clinicalSophia Schermerhorn0:50 ↗
Quality of Life Outcomes for Patients Who Underwent Conventional Resection and Liver Transplantation for Locally Advanced Hepatoblastoma
This is a single institution cross-sectional study using validated pediatric quality of life surveys to evaluate long-term survivors of hepatoblastoma.
clinicalSophia Schermerhorn0:24 ↗
Survival for hepatoblastoma continues to improve.
epidemiologicalSophia Schermerhorn0:18 ↗
Long-term quality of life is becoming a more important outcome as hepatoblastoma survival improves.
opinionSophia Schermerhorn0:18 ↗
Overall quality of life outcomes were similar between liver transplant and resection groups for hepatoblastoma.
clinicalSophia Schermerhorn0:31 ↗
There was no significant difference in emotional, social, physical, or school functioning outcomes between transplant and resection groups.
clinicalSophia Schermerhorn0:31 ↗
Patients who underwent resection had lower overall procedure anxiety scores than transplant patients.
clinicalSophia Schermerhorn0:47 ↗
The finding of lower procedural anxiety in resection patients was mirrored in the parents' surveys.
clinicalSophia Schermerhorn0:53 ↗
Long-term quality of life outcomes appear comparable between patients who undergo resection and liver transplantation for hepatoblastoma.
clinicalSophia Schermerhorn0:55 ↗
Surgical strategy for hepatoblastoma can be focused on oncologic control given comparable quality of life outcomes.
opinionSophia Schermerhorn1:02 ↗
Hepatoblastoma
Hepatoblastoma presents from the first year of life through perhaps 10 years of age, although there are a few that have been diagnosed older than that
epidemiologicalMax Langham2:19 ↗
If alpha fetoprotein is quite high and very elevated, the presumptive diagnosis in a 1 year old would be hepatoblastoma
clinicalMax Langham2:06 ↗
If it's a rhabdoid tumor, chemotherapy is not important and the lesion needs to be resected
clinicalMax Langham2:43 ↗
Most people favor needle biopsy of the liver rather than an open biopsy or a laparoscopic biopsy
guidelineMax Langham3:40 ↗
The biopsy should go through the normal part of the liver that will be resected with a specimen, approaching from the side of the tumor to avoid seeding
clinicalMax Langham3:51 ↗