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International Consensus Criteria for Pediatric Sepsis and Septic Shock

Video Published 2024-03-27 Updated 2026-06-29

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Topic Overview

International consensus establishes new pediatric sepsis definitions using the Phoenix sepsis score, which evaluates cardiovascular, respiratory, coagulation, and neurological dysfunction. Sepsis is defined as suspected infection plus 2 Phoenix points (7.1% mortality), while septic shock requires additional cardiovascular dysfunction (10.8-33.5% mortality depending on resources).

Key Takeaways

  • New Phoenix sepsis score uses 4 domains: cardiovascular, respiratory, coagulation, and neurological function to define pediatric sepsis
  • Pediatric sepsis now defined as suspected infection plus ≥2 points on Phoenix score; septic shock adds cardiovascular dysfunction (≥1 CV point)
  • Mortality rates correlate with definitions: sepsis 7.1%, septic shock 10.8-33.5% depending on resource setting
  • International Delphi consensus process updated sepsis definitions to better align clinical criteria with actual patient outcomes
  • Phoenix scoring system provides standardized, evidence-based criteria for identifying sepsis across different healthcare settings globally

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