ECMO timing and technique for severe congenital diaphragmatic hernia in neonates
The clinical scenario involves a full-term neonate with known left-sided very severe CDH, no cardiac or genetic anomalies, delivered about an hour ago and intubated per institutional protocols.
clinicalRebecca Stark0:55 ↗
Initial vitals show preductal saturations in the 70s, heart rate 150, blood pressure 35/25 on 100% FIO2, with first gas showing pH 6.8, PaCO2 130, and PaO2 28.
clinicalRebecca Stark1:09 ↗
The majority of centers still do VA ECMO primarily for CDH babies.
epidemiologicalRebecca Stark1:49 ↗
Both VA and VV ECMO are totally reasonable answers for this clinical scenario.
opinionRebecca Stark1:54 ↗
There are lots of benefits to VV ECMO and lots of benefits to VA ECMO.
opinionRebecca Stark1:45 ↗
Based on prenatal imaging showing high risk for needing ECMO, the time to intervene is probably earlier rather than later.
opinionRebecca Stark2:00 ↗
VV cannula availability and concerns with certain VV cannulas have played a role in ECMO modality selection.
opinion2:08 ↗
If an institution does VV ECMO but cannot cannulate because the 13 French cannula is too big, they would probably do VA instead.
clinicalRebecca Stark2:24 ↗
Better VV cannulas are coming out, which may change the numbers of centers using VV ECMO.
opinionRebecca Stark2:24 ↗
Michigan's SEER protocol prenatally selected severe CDH cases and educated parents they would go on this pathway.
guidelineRebecca Stark2:41 ↗
In the SEER protocol, ECMO was on standby in the delivery room, and babies were intubated and resuscitated within 2 hours.
guidelineRebecca Stark2:57 ↗
In the SEER protocol, if pH did not reach 7, PCO2 was not less than 100, and preductal sats were not above 80 within 2 hours, comfort measures only were offered.
guidelineRebecca Stark3:04 ↗
In the SEER protocol, if babies could achieve the resuscitation targets, they were offered ECMO.
Host summaryEm Gootee summarizing the discussion — not the host's own clinical position3:12 ↗
The two groups in the SEER protocol (ECMO versus comfort care) had equivalent survival.
epidemiologicalRebecca Stark3:16 ↗
Half of the patients offered comfort measures in the SEER protocol could have been survivors.
epidemiologicalRebecca Stark3:20 ↗
Half of the patients offered ECMO in the SEER protocol did not survive.
Host summaryEm Gootee summarizing the discussion — not the host's own clinical position3:26 ↗
If you make the decision to choose ECMO versus comfort care beforehand using protocols like SEER, you will be wrong 50% of the time.
opinionRebecca Stark3:30 ↗
With good prenatal counseling and parents who are all in, ECMO should be pursued for every unilateral isolated CDH.
opinionRebecca Stark3:38 ↗
Cases involving genetic or cardiac syndromes are an entirely different scenario from isolated CDH and are not included in the recommendation for universal ECMO.
opinionRebecca Stark3:49 ↗
Fetoscopic endoluminal tracheal occlusion for congenital diaphragmatic hernia
FETO is a percutaneous intervention on the mother using one trocar placed through the maternal abdominal wall into the uterus.
clinicalBeth Rymeski0:33 ↗
A standard fetoscope with a side channel is used, and the balloon is worked through the side channel.
clinicalBeth Rymeski0:36 ↗
The goal of FETO is to trap fluid in the lungs to allow the lungs to expand and grow.
Host summaryJill Knareth summarizes what Dr. Beth Romesky said — not the host's own clinical position0:47 ↗
FETO helps prevent pulmonary hypoplasia, which is a big factor in poor outcomes for CDH babies.
Host summaryJill Knareth summarizes what Dr. Beth Romesky said — not the host's own clinical position0:53 ↗
The tongue is an easy landmark to identify during FETO because it is bumpy.
clinicalBeth Rymeski1:21 ↗
Fluid is hooked up to the scope and can be intermittently turned on and off to push tissue away from the scope to allow easier advancement.
clinicalBeth Rymeski1:29 ↗
If the baby's head is not perfectly aligned with the scope, twisting and turning is required to navigate through the mouth.
clinicalBeth Rymeski1:39 ↗
The epiglottis is sought as a landmark to guide navigation toward the trachea.
clinicalBeth Rymeski1:58 ↗
Excessive torquing of the membranes should be avoided because the scope goes through the abdominal wall and uterine wall, and excessive turning can cause membrane damage.
clinicalBeth Rymeski2:23 ↗
The scope should always be advanced until the carina is visualized, which confirms location in the trachea and not the esophagus.
clinicalBeth Rymeski2:36 ↗
The balloon should not be driven into one side of the trachea; it must be inflated in the main trachea.
clinicalBeth Rymeski2:56 ↗