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Advances in Pediatric Surgery

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Profesor visitante Dr. Rodrigo Casals participa enseñando novedosa técnica quirúrgica
Profesor visitante Dr. Rodrigo Casals participa enseñando novedosa técnica quirúrgica Skip to main content Inicio Nosotros Equipo Profesores asociados Nuestra historia Docencia pregrado Docencia postgrado cirugía pediátrica Docencia postgra
article · Sep 2026
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The fetal frontier: A review of current and emerging fetal therapies for genetic diseases
Lizzy Lee from Cincinnati Children's discusses a pivotal review on 'The Fetal Frontier,' highlighting emerging therapies for genetic diseases. This video explores the innovative approaches of treating genetic conditions in the womb, leverag
video0:44 · May 2026
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Journal Reviews2 items
Journal of Pediatric Surgery Article Review: September 2021
We're highlighting three articles from the September 2021 issue of the Journal of Pediatric Surgery. We review the articles with Dr. Mikko Pakarinen (JPS Editor for Europe), Dr. Todd Ponsky, and two of the authors from one of the articles (
podcast11:16 · Oct 2021
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Quick Literature Updates Episode 2
We’re back with second episode of "Quick Literature Updates" the podcast series that delivers the latest updates in pediatric surgery literature in a quick and digestible format. In each episode, we review four articles covering the most in
video · Mar 2023
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Annual Updates1 item
2025 Pediatric Surgery Update Course - Updates in Pediatric Surgery feat. non-JPS Journals
On August 26th, the largest Pediatric Surgery course in the world each year was held, where top hospital experts from around the US will discuss this year’s changes in practices and innovation. Learn more about the future of pediatric surge
video22:32 · Aug 2025
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The fetal frontier: A review of current and emerging fetal therapies for genetic diseases
Faster prenatal diagnosis enables detection of many genetic conditions early
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:14 ↗
Medications can be given to the mother that cross the placenta
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:18 ↗
Enzyme replacement therapy can be delivered directly to the fetus
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:18 ↗
Protein therapy can be delivered to the fetus
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:24 ↗
Stem cells can be delivered to the fetus
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:24 ↗
The fetus has a more tolerant immune system compared to postnatal life
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:27 ↗
The fetus has a more permissive blood-brain barrier compared to postnatal life
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:27 ↗
Most fetal therapies for genetic diseases are still experimental
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:34 ↗
Fetal intervention aims to prevent lifelong disease by treating during fetal development
Host summaryLizzie Lee summarizing a resource — not the host's own clinical position0:38 ↗
Journal of Pediatric Surgery Article Review: September 2021
A Chinese randomized multi-center trial of 156 neonates who underwent surgery for gastrointestinal malformation with intestinal anastomosis compared early internal feeding versus traditional nasogastric decompression.
Host summaryRod Gerardo summarizing the discussion — not the host's own clinical position0:44 ↗
The early feeding group started feeds at 2 days compared to 6 days in the traditional feeding group.
Host summaryRod Gerardo summarizing the discussion — not the host's own clinical position0:44 ↗
There was no significant difference between early and traditional feeding groups in length of stay, time to full feeds, postoperative complications, 30-day mortality, or 30-day readmissions.
Host summaryRod Gerardo summarizing the discussion — not the host's own clinical position0:44 ↗
Although there is evidence that early feeding in adult patients after intestinal surgery is beneficial, the authors did not find any benefit in neonates.
clinicalMick Kakaran2:37 ↗
In the early feeding group, patients did not have a decompressing nasogastric tube, suggesting nasogastric decompression is not needed after neonatal intestinal anastomosis.
Host summaryRod Gerardo summarizing the discussion — not the host's own clinical position3:06 ↗
A Utah study examined patients under age 18 who presented with hematochezia to identify which factors predict Meckel diverticulum and created a risk score.
Host summaryRod Gerardo summarizing the discussion — not the host's own clinical position3:06 ↗
Babies with blood in their stool causing a decrease in hemoglobin has always been a red flag sign for Meckel diverticulum.
clinicalMick Kakaran3:06 ↗
The Meckel score could help clinicians skip the Meckel scan and go straight to laparoscopy in high-score patients, even with a negative scan.
Host summaryRod Gerardo summarizing the discussion — not the host's own clinical position3:06 ↗
A Cincinnati Children's study examined children aged 0-18 within a 15-mile radius who presented with perianal symptoms (abscess, fissure, fistula) to determine how often this represents Crohn disease.
clinicalIris Lim Butel7:23 ↗
Overall, 3% of children presenting with perianal symptoms were diagnosed with Crohn disease.
epidemiologicalIris Lim Butel9:02 ↗
No children under age 1 with perianal abscess ended up having Crohn disease within the study period.
epidemiologicalIris Lim Butel9:02 ↗
Higher rates of Crohn disease were seen in older children, particularly over age 10, among those presenting with perianal symptoms.
epidemiologicalJulian Goddard9:16 ↗
Many patients in the study had fissures, which are very common in children and may have been managed as outpatients.
clinicalIris Lim Butel9:41 ↗
Under age 10, clinicians do not need to worry about doing a workup for Crohn disease in children with perianal symptoms; over age 10, they should.
Host summaryRod Gerardo summarizing the discussion — not the host's own clinical position10:06 ↗
Quite a few children with Crohn disease present with perirectal abscess rather than typical GI symptoms like abdominal pain and diarrhea.
clinical10:23 ↗
2025 Pediatric Surgery Update Course - Updates in Pediatric Surgery feat. non-JPS Journals
The Chilean Society of Pediatric Surgery Journal Hive team screens through 1200 articles each month using a method to select high-quality publications
clinicalJose Campos0:48 ↗
The APPY trial is an international multicenter study comparing appendectomy versus antibiotics for acute uncomplicated appendicitis in children, with 936 patients aged 5-16 years randomized across 11 hospitals
Host summaryJose Campos summarizing the discussion — not the host's own clinical position4:33 ↗
In the APPY trial, treatment failure was defined differently in each arm: in the antibiotic group as appendectomy needed within one year, and in the surgical group as negative appendectomy or any procedure under general anesthesia related to appendicitis within one year
Host summaryJose Campos summarizing the discussion — not the host's own clinical position4:33 ↗
At one year in the APPY trial, 31% of children in the antibiotic group failed treatment compared with 7% in the appendectomy group, with the 26.7% difference exceeding the pre-specified 20% non-inferiority margin
Host summaryJose Campos summarizing the discussion — not the host's own clinical position4:33 ↗
Children in the antibiotic group of the APPY trial returned to school earlier and needed almost no pain medication
Host summaryJose Campos summarizing the discussion — not the host's own clinical position6:10 ↗
The APPY trial had 10% of patients with incomplete data and consent refusal reasons were not collected
Host summaryJose Campos summarizing the discussion — not the host's own clinical position6:10 ↗
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