Use of prostaglandin E1 to treat pulmonary hypertension in congenital diaphragmatic hernia

Retrospective study of 57 CDH neonates demonstrates that prostaglandin E1 therapy effectively reduces severe pulmonary hypertension by maintaining ductal patency and unloading the right ventricle. Treatment showed significant improvements in BNP levels and echocardiographic parameters without causing postductal hypoxemia or systemic hypoperfusion.