Prostaglandin E-major urinary metabolite as a noninvasive surrogate marker for infantile necrotizing enterocolitis

Study validates urinary prostaglandin E2 metabolite (PGE-MUM) as a noninvasive biomarker for necrotizing enterocolitis in infants, demonstrating 92.3% sensitivity and 81.5% specificity. PGE-MUM levels were significantly elevated in NEC patients compared to healthy controls, offering potential for earlier diagnosis than traditional Bell staging criteria.