Full-thickness rectal biopsy in children suspicious for Hirschsprung's disease is safe and yields a low number of insufficient biopsies

Retrospective study of 555 pediatric patients evaluating transanal full-thickness excision biopsy for Hirschsprung disease diagnosis. The technique demonstrated low inconclusive biopsy rate (5.9%) and identified aganglionosis in 12% of cases, with complications in 6.6% of patients—predominantly minor (Clavien-Dindo I-II).