In-vivo regeneration of bladder muscular wall with whole decellularized bladder matrix: A novel hourglass technique for duplication of bladder volume in rabbit model

This study demonstrates a novel hourglass technique for bladder augmentation using decellularized bladder matrix in a rabbit model, achieving bladder volume doubling with successful muscular wall regeneration. The technique avoids direct urine contact during the initial healing phase, resulting in superior tissue integration and reduced fibrosis compared to conventional augmentation methods.