Why This Procedure Exists
Congenital diaphragmatic hernia allows abdominal contents to herniate into the chest during fetal development, compressing the lungs and preventing normal growth 0:53. The resulting pulmonary hypoplasia — not the anatomic defect itself — drives mortality in severe cases 0:53. Fetoscopic endoluminal tracheal occlusion (FETO) addresses this by temporarily blocking the fetal trachea with a balloon, trapping lung fluid that would otherwise drain into the amniotic space 0:53. The retained fluid exerts outward pressure, promoting lung expansion and alveolar development during a critical window of gestation 0:53.
The Clinical Problem
Severe CDH presents a narrow therapeutic margin 0:53. Postnatal repair corrects the diaphragm but cannot reverse established pulmonary hypoplasia 0:53. By the time these infants reach the NICU, lung volume and vascular bed are fixed 0:53. FETO attempts to shift that trajectory in utero, buying lung growth before delivery 0:53. The procedure is not curative — these neonates still require complex postnatal management — but it aims to move them from non-viable to salvageable 0:53.
How the Approach Works
FETO is a single-trocar percutaneous procedure performed on the mother 0:33. Under ultrasound guidance, a trocar is placed through the maternal abdominal wall into the uterus 0:33. A standard fetoscope with a side channel is introduced, and a detachable balloon catheter is worked through that channel 0:42. The entire procedure is endoscopic; there is no hysterotomy 0:33.
Navigation begins at the fetal face 1:21. The nose and lips are identified first, followed by entry into the mouth 1:21. The tongue serves as a reliable landmark — it is bumpy and unmistakable on fetoscopy 1:21. From there, the operator advances toward the larynx, using intermittent fluid irrigation through the scope to displace soft tissue and improve visualization 1:29. If the fetal head is not aligned with the scope axis, gentle manipulation is required, though excessive torquing must be avoided because the scope traverses both the abdominal and uterine walls, and aggressive turning risks membrane damage 2:23.
The epiglottis is the next critical landmark 1:58. Once identified, the scope is advanced through the vocal cords into the trachea 1:58. Esophageal intubation is a recognized pitfall — the esophagus may be encountered first, requiring scope withdrawal and reorientation 2:36. To confirm tracheal placement, the operator always advances until the carina is visualized 2:36. Seeing the bifurcation eliminates doubt about location and provides a reference point for balloon positioning 2:36.
The balloon is deployed just above the carina but well below the vocal cords 2:56. Positioning is critical: the balloon must sit in the main trachea, not wedged into a mainstem bronchus 2:56. As the balloon is inflated, the scope is withdrawn slightly to allow direct visualization of the inflation 3:03. The balloon is filled with 0.65 to 0.8 mL of water, adjusted for tracheal diameter 3:08. A small metal ball embedded in the balloon provides a radiographic marker for postnatal localization 3:29.
Once inflated, the balloon is detached from the delivery catheter 3:40. Final confirmation requires advancing the scope one more time to verify that the balloon sits below the vocal cords and within the main trachea 3:40. Occasionally the trocar advances into the fetal mouth during manipulation and must be withdrawn 3:33. The scope is then removed, the trocar is withdrawn, and the uterine puncture seals spontaneously 0:33.
What Remains Uncertain
This discussion focuses on procedural technique rather than patient selection or outcomes. The ledger does not address which fetuses benefit most, the optimal gestational age for balloon placement, timing of balloon removal, or comparative survival data. Those questions are central to clinical decision-making but are not covered here.
The procedure itself is technically demanding 2:23. Fetal positioning, amniotic fluid volume, and maternal body habitus all affect feasibility 2:23. The discussion hints at the need for real-time adjustments — scope angulation, fluid irrigation, and gentle persistence — but does not quantify failure rates or describe rescue maneuvers when anatomy is unfavorable.
When to Involve This Team
FETO is not a general fetal surgery intervention. It is performed at a small number of centers with dedicated fetal therapy programs, typically for severe left-sided CDH diagnosed on prenatal ultrasound with lung-to-head ratio or observed-to-expected lung volume measurements below defined thresholds. Referral should occur as soon as severe CDH is suspected to allow time for multidisciplinary evaluation, parental counseling, and procedural planning if the fetus meets criteria. The window for intervention is narrow, and balloon placement timing must be carefully planned. Any obstetrician managing a pregnancy with suspected severe CDH should initiate contact with a fetal center early, even if the family has not yet decided on intervention. The evaluation itself takes time, and delaying referral forecloses the option.
Takeaways from this story
- FETO is a single-trocar percutaneous procedure on the mother, not a hysterotomy-based fetal surgery.
- Visualizing the carina confirms tracheal placement and prevents esophageal balloon deployment.
- Excessive scope torquing risks membrane damage because the instrument traverses abdominal and uterine walls.
- Balloon volume is individualized (0.65-0.8 mL) based on tracheal diameter to avoid mainstem occlusion.