Christina Theodorou

88 timestamped statements across 6 topics — auto-found in recorded discussions, each timestamp jumps to the exact moment.

Featured statements

▶ Ep 20 · 3:27
We expose the fetal back, we re-expose the spinal cord, we identify the MMC defect, and then we take our extracellular matrix patch that has the placental. Stem cells on it, it is, uh, placed with the cells facing the spinal cord in direct contact, and then the skin is closed and the baby is returned to the uterus to continue gestation until term.
quote · Fetal Surgery
▶ Ep 20 · 3:54
And we found that lambs were paired with these clinical grade subfrontal stem cells have significantly improved motor function compared to lambs that did not receive the stem cells.
quote · Fetal Surgery
▶ Ep 19 · 4:40
The ideal diaphragm replacement would integrate with native tissue, mechanically match the function of the diaphragm, and allow for growth with the child.
quote · Congenital Diaphragmatic Hernia
▶ Ep 22 · 0:00
The ideal diaphragm replacement would integrate with native tissue, mechanically match the function of the diaphragm and allow for growth with the child.
quote · Congenital Diaphragmatic Hernia
▶ Ep 6 · 3:27
The technique involves exposing the fetal back, re-exposing the spinal cord, identifying the myelomeningocele defect, placing an extracellular matrix patch with placental stem cells facing the spinal cord in direct contact, closing the skin, and returning the baby to the uterus to continue gestation until term.
clinical · Myelomeningocele
▶ Ep 1 · 3:53
Synthetic patches such as PTFE or Gore-Tex used for large diaphragmatic defects are associated with significant morbidity, including hernia recurrence, bowel obstructions, and chest wall deformities as the child grows.
clinical · Hernia Recurrence

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Christina's statements about Congenital Diaphragmatic Hernia 32 statements

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BOB in Ped Surg 2023 - CAPS Winner - Christina Theodorou, MD

▶ Ep 19 · 3:53
quote The optimal management of congenital diaphragmatic hernia is an area of active research. ↗
▶ Ep 19 · 3:53
clinical Synthetic patches such as PTFE or Gore-Tex used for large diaphragmatic defects are associated with significant morbidity, including hernia recurrence, bowel obstructions, and chest wall deformities as the child grows. ↗
▶ Ep 19 · 4:40
clinical Biodegradable forms of polyurethane have been used in tissue repair recently, such as vascular and muscular tissue replacement, and have high mechanical strength. ↗
▶ Ep 19 · 4:40
quote The ideal diaphragm replacement would integrate with native tissue, mechanically match the function of the diaphragm, and allow for growth with the child. ↗
▶ Ep 19 · 5:10
quote We hypothesized that this novel PU based patch would be durable and would not result in recurrent herniation. Additionally, the elastic nature of the patch would allow for more diaphragmatic excursion than gortex. ↗
▶ Ep 19 · 5:10
clinical In the rat model study, 4mm diaphragmatic defects were created followed by immediate patch repair, with six animals in each cohort plus a sham cohort of six rats. ↗
▶ Ep 19 · 6:00
clinical No recurrences were seen in either the polyurethane or Gore-Tex cohort at four weeks. ↗
▶ Ep 19 · 6:10
clinical At one week, there was no difference in diaphragmatic excursion between sham, Gore-Tex and polyurethane animals. ↗
▶ Ep 19 · 6:20
clinical At four weeks, Gore-Tex had limited diaphragm rise compared to sham, but no difference was found between polyurethane and sham. ↗
▶ Ep 19 · 6:35
clinical There were no differences in diaphragmatic excursion between polyurethane and Gore-Tex at any time point. ↗
▶ Ep 19 · 6:45
clinical An inflammatory capsule was formed surrounding both patches, with no significant difference in the size of that inflammatory capsule between the cohorts. ↗
▶ Ep 19 · 7:10
clinical The study had small numbers of animals in each cohort, likely underpowering detection of significant differences. ↗
▶ Ep 19 · 7:20
clinical Most recurrences of diaphragmatic hernia occur at least a few months out from surgery, most commonly within the first two years. ↗

BOB Ped Surg 2023 - Christina Theodorou, CAPS - Presentation

▶ Ep 22 · 0:00
quote The ideal diaphragm replacement would integrate with native tissue, mechanically match the function of the diaphragm and allow for growth with the child. ↗
▶ Ep 22 · 0:00
opinion The ideal diaphragm replacement would integrate with native tissue, mechanically match the function of the diaphragm and allow for growth with the child. ↗
▶ Ep 22 · 0:00
clinical Synthetic patches for diaphragmatic hernia repair are associated with significant morbidity including hernia recurrence, bowel obstructions, and chest wall deformities as the child grows. ↗
▶ Ep 22 · 0:00
clinical In cases of large congenital diaphragmatic hernia defects, diaphragmatic replacements are used, most commonly synthetic patches such as PTFE or Gore-Tex. ↗
▶ Ep 22 · 1:00
clinical Biodegradable forms of polyurethane have been used in tissue repair recently such as vascular and muscular tissue replacement and have high mechanical strength. ↗
▶ Ep 22 · 1:00
clinical The study created 4 mm diaphragmatic defects in rats followed by immediate patch repair, with cohorts of six animals each plus a sham cohort of six rats. ↗
▶ Ep 22 · 1:00
quote We hypothesized that this novel PU-based patch would be durable and would not result in recurrent herniation. Additionally, the elastic nature of the patch would allow for more diaphragmatic excursion than Gore-Tex. ↗
▶ Ep 22 · 1:00
clinical Animals were survived for four weeks with fluoroscopic evaluation of diaphragmatic excursion at one and four weeks post-op. ↗
▶ Ep 22 · 2:00
clinical At one week post-op, there was no difference in diaphragmatic excursion between sham, Gore-Tex, and polyurethane animals. ↗
▶ Ep 22 · 2:00
clinical At four weeks, Gore-Tex had limited diaphragm rise compared to sham, but no difference was found between polyurethane and sham. ↗
▶ Ep 22 · 2:00
clinical There were no differences in diaphragmatic excursion between polyurethane and Gore-Tex at any time point. ↗
▶ Ep 22 · 2:00
clinical No recurrences were seen in either the polyurethane or Gore-Tex cohort at four weeks. ↗
▶ Ep 22 · 2:00
quote No recurrences were seen in either cohort. ↗
▶ Ep 22 · 2:00
quote At four weeks, Gore-Tex had limited diaphragm rise compared to sham, but no difference was found between PU and sham. ↗
▶ Ep 22 · 3:00
clinical An inflammatory capsule was formed surrounding both polyurethane and Gore-Tex patches. ↗
▶ Ep 22 · 3:00
clinical There was no significant difference in the size of the inflammatory capsule between the polyurethane and Gore-Tex cohorts. ↗
▶ Ep 22 · 3:00
clinical The study had small numbers of animals in each cohort (six per group), likely under powering detection of significant differences. ↗
▶ Ep 22 · 3:00
clinical Most diaphragmatic hernia recurrences occur at least a few months out from surgery, most commonly within the first two years. ↗
▶ Ep 22 · 3:00
clinical The biodegradation rate of the polyurethane patch can be altered to match the rate of tissue in-growth with the goal of complete replacement over time with native diaphragm tissue. ↗
Christina's statements about Fetal Surgery 6 statements

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Journal of Pediatric Surgery Article Highlights: April 2022

▶ Ep 20 · 2:54
quote This study, a pivotal study in obtaining approval from the FDA for use of clinical grade stem cells in fetal myeloma meningocele repair. ↗
▶ Ep 20 · 2:54
clinical Dr. Christina Theodoro states this study is a pivotal study in obtaining approval from the FDA for use of clinical grade stem cells in fetal myelomeningocele repair. ↗
▶ Ep 20 · 3:27
clinical The technique involves exposing the fetal back, re-exposing the spinal cord, identifying the myelomeningocele defect, placing an extracellular matrix patch with placental stem cells facing the spinal cord in direct contact, closing the skin, and returning the baby to the uterus to continue gestation until term. ↗
▶ Ep 20 · 3:27
quote We expose the fetal back, we re-expose the spinal cord, we identify the MMC defect, and then we take our extracellular matrix patch that has the placental. Stem cells on it, it is, uh, placed with the cells facing the spinal cord in direct contact, and then the skin is closed and the baby is returned to the uterus to continue gestation until term. ↗
▶ Ep 20 · 3:54
quote And we found that lambs were paired with these clinical grade subfrontal stem cells have significantly improved motor function compared to lambs that did not receive the stem cells. ↗
▶ Ep 20 · 3:54
clinical Lambs repaired with clinical grade placental stem cells have significantly improved motor function compared to lambs that did not receive the stem cells. ↗
Christina's statements about Hernia Recurrence 32 statements

Open the Hernia Recurrence collection →

BOB in Ped Surg 2023 - CAPS Winner - Christina Theodorou, MD

▶ Ep 1 · 3:53
clinical Synthetic patches such as PTFE or Gore-Tex used for large diaphragmatic defects are associated with significant morbidity, including hernia recurrence, bowel obstructions, and chest wall deformities as the child grows. ↗
▶ Ep 1 · 3:53
quote The optimal management of congenital diaphragmatic hernia is an area of active research. ↗
▶ Ep 1 · 4:40
quote The ideal diaphragm replacement would integrate with native tissue, mechanically match the function of the diaphragm, and allow for growth with the child. ↗
▶ Ep 1 · 4:40
clinical Biodegradable forms of polyurethane have been used in tissue repair recently, such as vascular and muscular tissue replacement, and have high mechanical strength. ↗
▶ Ep 1 · 5:10
clinical In the rat model study, 4mm diaphragmatic defects were created followed by immediate patch repair, with six animals in each cohort plus a sham cohort of six rats. ↗
▶ Ep 1 · 5:10
quote We hypothesized that this novel PU based patch would be durable and would not result in recurrent herniation. Additionally, the elastic nature of the patch would allow for more diaphragmatic excursion than gortex. ↗
▶ Ep 1 · 6:00
clinical No recurrences were seen in either the polyurethane or Gore-Tex cohort at four weeks. ↗
▶ Ep 1 · 6:10
clinical At one week, there was no difference in diaphragmatic excursion between sham, Gore-Tex and polyurethane animals. ↗
▶ Ep 1 · 6:20
clinical At four weeks, Gore-Tex had limited diaphragm rise compared to sham, but no difference was found between polyurethane and sham. ↗
▶ Ep 1 · 6:35
clinical There were no differences in diaphragmatic excursion between polyurethane and Gore-Tex at any time point. ↗
▶ Ep 1 · 6:45
clinical An inflammatory capsule was formed surrounding both patches, with no significant difference in the size of that inflammatory capsule between the cohorts. ↗
▶ Ep 1 · 7:10
clinical The study had small numbers of animals in each cohort, likely underpowering detection of significant differences. ↗
▶ Ep 1 · 7:20
clinical Most recurrences of diaphragmatic hernia occur at least a few months out from surgery, most commonly within the first two years. ↗

BOB Ped Surg 2023 - Christina Theodorou, CAPS - Presentation

▶ Ep 2 · 0:00
quote The ideal diaphragm replacement would integrate with native tissue, mechanically match the function of the diaphragm and allow for growth with the child. ↗
▶ Ep 2 · 0:00
opinion The ideal diaphragm replacement would integrate with native tissue, mechanically match the function of the diaphragm and allow for growth with the child. ↗
▶ Ep 2 · 0:00
clinical Synthetic patches for diaphragmatic hernia repair are associated with significant morbidity including hernia recurrence, bowel obstructions, and chest wall deformities as the child grows. ↗
▶ Ep 2 · 0:00
clinical In cases of large congenital diaphragmatic hernia defects, diaphragmatic replacements are used, most commonly synthetic patches such as PTFE or Gore-Tex. ↗
▶ Ep 2 · 1:00
quote We hypothesized that this novel PU-based patch would be durable and would not result in recurrent herniation. Additionally, the elastic nature of the patch would allow for more diaphragmatic excursion than Gore-Tex. ↗
▶ Ep 2 · 1:00
clinical Biodegradable forms of polyurethane have been used in tissue repair recently such as vascular and muscular tissue replacement and have high mechanical strength. ↗
▶ Ep 2 · 1:00
clinical The study created 4 mm diaphragmatic defects in rats followed by immediate patch repair, with cohorts of six animals each plus a sham cohort of six rats. ↗
▶ Ep 2 · 1:00
clinical Animals were survived for four weeks with fluoroscopic evaluation of diaphragmatic excursion at one and four weeks post-op. ↗
▶ Ep 2 · 2:00
clinical There were no differences in diaphragmatic excursion between polyurethane and Gore-Tex at any time point. ↗
▶ Ep 2 · 2:00
quote At four weeks, Gore-Tex had limited diaphragm rise compared to sham, but no difference was found between PU and sham. ↗
▶ Ep 2 · 2:00
clinical No recurrences were seen in either the polyurethane or Gore-Tex cohort at four weeks. ↗
▶ Ep 2 · 2:00
clinical At one week post-op, there was no difference in diaphragmatic excursion between sham, Gore-Tex, and polyurethane animals. ↗
▶ Ep 2 · 2:00
clinical At four weeks, Gore-Tex had limited diaphragm rise compared to sham, but no difference was found between polyurethane and sham. ↗
▶ Ep 2 · 2:00
quote No recurrences were seen in either cohort. ↗
▶ Ep 2 · 3:00
clinical The study had small numbers of animals in each cohort (six per group), likely under powering detection of significant differences. ↗
▶ Ep 2 · 3:00
clinical Most diaphragmatic hernia recurrences occur at least a few months out from surgery, most commonly within the first two years. ↗
▶ Ep 2 · 3:00
clinical An inflammatory capsule was formed surrounding both polyurethane and Gore-Tex patches. ↗
▶ Ep 2 · 3:00
clinical There was no significant difference in the size of the inflammatory capsule between the polyurethane and Gore-Tex cohorts. ↗
▶ Ep 2 · 3:00
clinical The biodegradation rate of the polyurethane patch can be altered to match the rate of tissue in-growth with the goal of complete replacement over time with native diaphragm tissue. ↗
Christina's statements about Myelomeningocele 6 statements

Open the Myelomeningocele collection →

Journal of Pediatric Surgery Article Highlights: April 2022

▶ Ep 6 · 2:54
clinical Dr. Christina Theodoro states this study is a pivotal study in obtaining approval from the FDA for use of clinical grade stem cells in fetal myelomeningocele repair. ↗
▶ Ep 6 · 2:54
quote This study, a pivotal study in obtaining approval from the FDA for use of clinical grade stem cells in fetal myeloma meningocele repair. ↗
▶ Ep 6 · 3:27
clinical The technique involves exposing the fetal back, re-exposing the spinal cord, identifying the myelomeningocele defect, placing an extracellular matrix patch with placental stem cells facing the spinal cord in direct contact, closing the skin, and returning the baby to the uterus to continue gestation until term. ↗
▶ Ep 6 · 3:27
quote We expose the fetal back, we re-expose the spinal cord, we identify the MMC defect, and then we take our extracellular matrix patch that has the placental. Stem cells on it, it is, uh, placed with the cells facing the spinal cord in direct contact, and then the skin is closed and the baby is returned to the uterus to continue gestation until term. ↗
▶ Ep 6 · 3:54
quote And we found that lambs were paired with these clinical grade subfrontal stem cells have significantly improved motor function compared to lambs that did not receive the stem cells. ↗
▶ Ep 6 · 3:54
clinical Lambs repaired with clinical grade placental stem cells have significantly improved motor function compared to lambs that did not receive the stem cells. ↗
Christina's statements about Pediatric Oncology 6 statements

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Journal of Pediatric Surgery Article Highlights: April 2022

▶ Ep 370 · 2:54
quote This study, a pivotal study in obtaining approval from the FDA for use of clinical grade stem cells in fetal myeloma meningocele repair. ↗
▶ Ep 370 · 2:54
clinical Dr. Christina Theodoro states this study is a pivotal study in obtaining approval from the FDA for use of clinical grade stem cells in fetal myelomeningocele repair. ↗
▶ Ep 370 · 3:27
clinical The technique involves exposing the fetal back, re-exposing the spinal cord, identifying the myelomeningocele defect, placing an extracellular matrix patch with placental stem cells facing the spinal cord in direct contact, closing the skin, and returning the baby to the uterus to continue gestation until term. ↗
▶ Ep 370 · 3:27
quote We expose the fetal back, we re-expose the spinal cord, we identify the MMC defect, and then we take our extracellular matrix patch that has the placental. Stem cells on it, it is, uh, placed with the cells facing the spinal cord in direct contact, and then the skin is closed and the baby is returned to the uterus to continue gestation until term. ↗
▶ Ep 370 · 3:54
clinical Lambs repaired with clinical grade placental stem cells have significantly improved motor function compared to lambs that did not receive the stem cells. ↗
▶ Ep 370 · 3:54
quote And we found that lambs were paired with these clinical grade subfrontal stem cells have significantly improved motor function compared to lambs that did not receive the stem cells. ↗
Christina's statements about Wilms Tumor 6 statements

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Journal of Pediatric Surgery Article Highlights: April 2022

▶ Ep 12 · 2:54
quote This study, a pivotal study in obtaining approval from the FDA for use of clinical grade stem cells in fetal myeloma meningocele repair. ↗
▶ Ep 12 · 2:54
clinical Dr. Christina Theodoro states this study is a pivotal study in obtaining approval from the FDA for use of clinical grade stem cells in fetal myelomeningocele repair. ↗
▶ Ep 12 · 3:27
quote We expose the fetal back, we re-expose the spinal cord, we identify the MMC defect, and then we take our extracellular matrix patch that has the placental. Stem cells on it, it is, uh, placed with the cells facing the spinal cord in direct contact, and then the skin is closed and the baby is returned to the uterus to continue gestation until term. ↗
▶ Ep 12 · 3:27
clinical The technique involves exposing the fetal back, re-exposing the spinal cord, identifying the myelomeningocele defect, placing an extracellular matrix patch with placental stem cells facing the spinal cord in direct contact, closing the skin, and returning the baby to the uterus to continue gestation until term. ↗
▶ Ep 12 · 3:54
clinical Lambs repaired with clinical grade placental stem cells have significantly improved motor function compared to lambs that did not receive the stem cells. ↗
▶ Ep 12 · 3:54
quote And we found that lambs were paired with these clinical grade subfrontal stem cells have significantly improved motor function compared to lambs that did not receive the stem cells. ↗