Tracheal Allotransplantation to Deliver Growing Airway Implants for Infants and Children

Abstract

The first successful organ transplantation was performed by Dr. Joseph Murray at The Peter Bent Brigham Hospital in 1954 [1]. After the transplantation of a kidney between two identical twin brothers, the recipient survived eight years without immunosuppression. By the early 60s, allotransplantation involving non-perfect matchesfinally proved successful by leveraging pharmacologic immunosuppression with cyclophosphamide and methotrexate [1]. In the following decades, more organs began to be successfully transplanted, including the heart in 1967, the heart/lung block in 1981 and the lungs in 1983 [1].

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