Disruption of enterohepatic Circulation of Bile acids ameliorates small bowel resection associated hepatic injury
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- Distal small bowel resection (including ileocecal valve) causes less liver injury than proximal resection in mouse models.
- Disrupting enterohepatic circulation of bile acids reduces hepatic oxidative stress after bowel resection.
- Distal resection produces a more hydrophilic bile acid profile, which may be hepatoprotective.
- Ileocecal resection may offer liver protection in short bowel syndrome compared to proximal resections.
- Bile acid composition, not just malabsorption, drives intestinal failure-associated liver disease pathophysiology.
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Did you know that the disruption of the enterohepatic circulation of bile acids is is beneficial for the liver? Hi, I'm Cecilia Higera from Cincinnati Children's Hospital, and this is an article that you should know about. This is a basic science study done in St. Louis Children's Hospital. And their aim was to elucidate the driving force behind the hepatic injury. For that, they have three groups of mice: Sham, 50% with proximal or deudinal resection, and 50% with distal resection, or the resection of the ileocecal bulb. And then they took tissue samples at the second and 10th post-op weeks. And what did they find? They find that mice with distal resection show less hepatic oxidative stress and more hydrophilic bile acid profile, meaning that the ileocecal resection could lead to less hepatic injury. Let us know what you think and stay tuned for more articles that you should know about.