The Development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach.
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Nov 2026 · 1 min read
In brief
In brief
This study investigates how age affects the emergence of spasmolytic polypeptide-expressing metaplasia (SPEM) during gastric ulcer healing. Research reveals that aged gastric tissue shows impaired SPEM development following parietal cell loss, potentially explaining reduced repair capacity and increased ulcer susceptibility in elderly patients.
Written by the GCMD Library team from the article.
Statements in this article
During aging, physiological changes in the stomach result in less capable tissue for repairing injury, leading to increased susceptibility to chronic ulceration.
Spasmolytic polypeptide/trefoil factor 2-expressing metaplasia (SPEM) emerges after parietal cell loss and during Helicobacter pylori infection.
The role of SPEM in gastric ulcer repair is unknown.