Article1 min read·Published Jan 2018Older

Cardiovascular Risk Factors After Adolescent Bariatric Surgery

Part of Adolescent Bariatric Surgery 39 items

pubmed.ncbi.nlm.nih.gov

Michael Helmrath

Background And Objectives: Severely obese adolescents harbor numerous cardiovascular disease risk factors (CVD-RFs), which improve after metabolic and bariatric surgery (MBS). However, predictors of change in CVD-RFs among adolescents have not yet been reported. Methods: The Teen-Longitudinal Assessment of Bariatric Surgery study (NCT00474318) prospectively collected anthropometric and health status data on 242 adolescents undergoing MBS at 5 centers. Predictors of change in CVD-RFs (blood pressure, lipids, glucose homeostasis, and inflammation) 3 years after Roux-en-Y gastric bypass and vertical sleeve gastrectomy were examined. Results: The mean (±SD) age of participants at baseline was 17 ± 1.6 years; 76% were girls, and 72% were white, with a median BMI of 51. Participants underwent Roux-en-Y gastric bypass (n = 161), vertical sleeve gastrectomy (n = 67), or adjustable gastric banding (n = 14). Increasing weight loss was an independent predictor of normalization in dyslipidemia, elevated blood pressure (EBP), hyperinsulinemia, diabetes, and elevated high-sensitivity C-reactive protein. Older participants at time of surgery were less likely to resolve dyslipidemia compared with younger participants, whereas girls were more likely than boys to demonstrate improvements in EBP. Even those participants without frank dyslipidemia or EBP at baseline showed significant improvements in lipid and blood pressure values over time. Conclusions: Numerous CVD-RFs improve among adolescen

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Article · Jan 2018 · 1 min read

In brief

This prospective Teen-LABS study of 242 adolescents undergoing bariatric surgery demonstrates that greater weight loss independently predicts normalization of cardiovascular risk factors including dyslipidemia, elevated blood pressure, and hyperinsulinemia at 3 years post-surgery. Younger age at surgery and female sex were associated with better cardiovascular outcomes, with improvements observed even in patients without baseline abnormalities.

Written by the GCMD Library team from the article.

Michael Helmrath

Statements in this article

Severely obese adolescents harbor numerous cardiovascular disease risk factors that improve after metabolic and bariatric surgery.
EstablishedBackground And Objectives
The Teen-Longitudinal Assessment of Bariatric Surgery study prospectively collected anthropometric and health status data on 242 adolescents undergoing metabolic and bariatric surgery at 5 centers.
ResearchMethods
Predictors of change in cardiovascular disease risk factors including blood pressure, lipids, glucose homeostasis, and inflammation were examined 3 years after Roux-en-Y gastric bypass and vertical sleeve gastrectomy.
ResearchMethods
The mean age of participants at baseline was 17 ± 1.6 years, 76% were girls, 72% were white, with a median BMI of 51.
ResearchResults
Participants underwent Roux-en-Y gastric bypass (n = 161), vertical sleeve gastrectomy (n = 67), or adjustable gastric banding (n = 14).
ResearchResults
Increasing weight loss was an independent predictor of normalization in dyslipidemia, elevated blood pressure, hyperinsulinemia, diabetes, and elevated high-sensitivity C-reactive protein.
ResearchResults
Older participants at time of surgery were less likely to resolve dyslipidemia compared with younger participants.
ResearchResults
Girls were more likely than boys to demonstrate improvements in elevated blood pressure.
ResearchResults
Participants without frank dyslipidemia or elevated blood pressure at baseline showed significant improvements in lipid and blood pressure values over time.
ResearchResults
Numerous cardiovascular disease risk factors improve among adolescents after metabolic and bariatric surgery.
ResearchConclusions