Article1 min read·Published Aug 2013Older

Multiple micronutrient deficiencies among patients with intestinal failure during and after transition to enteral nutrition

Part of Short Bowel Syndrome & Intestinal Failure 8 items

pubmed.ncbi.nlm.nih.gov

Michael Helmrath

Objectives: To determine the prevalence of deficiencies of specific micronutrients (iron, zinc, magnesium, phosphorus, selenium, copper, folate, and vitamins A, D, E, and B12) in children with intestinal failure (IF), and to identify risk factors associated with developing these deficiencies. Study Design: This study was a retrospective review of prospectively collected data from 178 children with IF managed by the Intestinal Care Center of Cincinnati Children's Hospital Medical Center between August 1, 2007, and July 31, 2012. Transition to full enteral nutrition (FEN) was defined as the period during which the patient received between 20% and 100% of estimated required nutrition enterally. FEN was defined as the patient's ability to tolerate 100% estimated required nutrition enterally for >2 weeks. Results: Necrotizing enterocolitis was the most common cause of IF (27.5%). Iron was the most common micronutrient deficiency identified both during (83.9%) and after (61%) successful transition to FEN, with a significant reduction in the percentage of patients with iron deficiency between these 2 periods (P = .003). Predictors of micronutrient deficiency after successful transition to FEN included birth weight (P = .03), weight percentile (P = .02), height percentile (P = .04), and duration of parenteral nutrition (PN) (P = .013). After multivariate adjustments, only duration of PN remained statistically significant (P = .03). Conclusion: Micronutrient deficiencies persist in pa

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Article · Aug 2013 · 1 min read

In brief

This retrospective study of 178 children with intestinal failure found that micronutrient deficiencies—particularly iron (83.9%)—persist during and after transition to full enteral nutrition. Duration of parenteral nutrition was the strongest predictor of ongoing deficiencies, highlighting the need for vigilant monitoring during nutritional rehabilitation.

Written by the GCMD Library team from the article.

Michael Helmrath

Statements in this article

Necrotizing enterocolitis was the most common cause of intestinal failure, accounting for 27.5% of cases.
ResearchResults
Iron was the most common micronutrient deficiency identified during transition to full enteral nutrition, affecting 83.9% of patients.
ResearchResults
Iron deficiency persisted after successful transition to full enteral nutrition in 61% of patients.
ResearchResults
The percentage of patients with iron deficiency significantly decreased between the transition period and after achieving full enteral nutrition (P = .003).
ResearchResults
Birth weight is a predictor of micronutrient deficiency after successful transition to full enteral nutrition (P = .03).
ResearchResults
Weight percentile is a predictor of micronutrient deficiency after successful transition to full enteral nutrition (P = .02).
ResearchResults
Height percentile is a predictor of micronutrient deficiency after successful transition to full enteral nutrition (P = .04).
ResearchResults
Duration of parenteral nutrition is a predictor of micronutrient deficiency after successful transition to full enteral nutrition (P = .013).
ResearchResults
After multivariate adjustments, only duration of parenteral nutrition remained statistically significant as a predictor of micronutrient deficiency (P = .03).
ResearchResults
Micronutrient deficiencies persist in patients with intestinal failure even after successful transition to full enteral nutrition.
ResearchConclusion