Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling.
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Nov 2026 · 1 min read
In brief
In brief
This study describes a novel protocol for generating human colonic organoids from pluripotent stem cells by transiently activating BMP signaling. The technique addresses previous challenges in deriving distal gut tissues in vitro, providing a new model system for studying colonic development and disease.
Written by the GCMD Library team from the article.
Statements in this article
Gastric and small intestinal organoids differentiated from human pluripotent stem cells have revolutionized the study of gastrointestinal development and disease.
Distal gut tissues such as cecum and colon have proved considerably more challenging to derive in vitro than gastric and small intestinal organoids.
Human colonic organoids can be differentiated from human pluripotent stem cells.
BMP signaling is required for the differentiation of human pluripotent stem cells into colonic organoids.