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Pediatric and Young Adult Image-Guided Percutaneous Bone Biopsy-A New Standard of Care?

Video Published 2026-02-20 Updated 2026-02-20

Timestops (3)

0:00
Are you still doing open biopsy for pediatric bone tumors?
Are you still doing open biopsy for pediatric bone tumors? Hi, I'm Doctor Sophia Schermerhorn from Cincinnati Children's…
0:28
All of these biopsies were performed by interventional radio…
All of these biopsies were performed by interventional radiologists. The diagnostic yield was impressive. 97.9% of biops…
0:43
0.7% complication rate.
0.7% complication rate. Importantly, this approach provided sufficient tissue, not just for histology, but from immunost…

Topic Overview

A single-institution retrospective series of 169 image-guided percutaneous biopsies in 141 pediatric and young adult patients over 10 years demonstrated a 97.9% diagnostic yield with only a 0.7% complication rate. Nearly 90% were core-needle biopsies performed by interventional radiologists, most commonly using CT guidance. The tissue obtained was sufficient for histology, immunostains, and molecular studies required for modern risk stratification and targeted therapy.

Key Takeaways

  • Image-guided percutaneous bone biopsy achieved 97.9% diagnostic yield with only 0.7% complication rate in pediatric patients. (0:33)
  • Core-needle biopsy provided sufficient tissue for histology, immunostains, and molecular studies needed for risk stratification. (0:19)
  • Interventional radiologists performed all biopsies using CT guidance, with only 3 of 169 patients requiring repeat procedure. (0:22)
  • Image-guided percutaneous biopsy should be strongly considered first-line for pediatric bone and soft tissue tumor diagnosis. (0:56)

Inside this episode

Kai, the Library's AI content creator, listened to this episode and mapped who's speaking, the chapters, key claims, and cases. Every item links to the exact moment in the recording.

AI-enriched

Who's speaking

  • Dr. Sophia Schermerhorn — host

Chapters

  • 0:00Image-Guided Percutaneous Biopsy for Pediatric Bone Tumors — Dr. Schermerhorn presents a 10-year single-institution series evaluating image-guided percutaneous biopsy as a potential standard of care for pediatric and young adult bone and soft tissue masses, highlighting diagnostic yield, safety profile, and tissue adequacy for molecular studies.

Key claims

  • 0:13The study evaluated 169 biopsies in 141 patients over a 10-year period at a single institution. — Dr. Sophia Schermerhorn
  • 0:19Nearly 90% of the biopsies were core-needle biopsies. — Dr. Sophia Schermerhorn
  • 0:22All biopsies were performed with image guidance, most commonly CT, sometimes combined with fluoroscopy and ultrasound. — Dr. Sophia Schermerhorn
  • 0:28All biopsies were performed by interventional radiologists. — Dr. Sophia Schermerhorn
  • 0:3397.9% of biopsies were diagnostic. — Dr. Sophia Schermerhorn
  • 0:33Only 3 patients required repeat biopsy. — Dr. Sophia Schermerhorn
  • 0:40There was one patient with transient sciatic nerve paresis, which resolved. — Dr. Sophia Schermerhorn
  • 0:43The complication rate was 0.7%. — Dr. Sophia Schermerhorn
  • 0:46The approach provided sufficient tissue for histology, immunostains, and molecular studies. — Dr. Sophia Schermerhorn
  • 0:46Immunostains and molecular studies are increasingly essential for modern risk stratification and targeted therapy. — Dr. Sophia Schermerhorn
  • 0:56Image-guided percutaneous biopsy should be strongly considered the diagnostic modality of choice for pediatric bone and soft tissue tumors. — Dr. Sophia Schermerhorn
This episode was analyzed and enriched by Kai, the Library's AI content creator. Every item links to the moment it comes from — click a timestamp to listen in context.

Keywords

pediatric bone tumors soft tissue masses transient sciatic nerve paresis image-guided percutaneous biopsy core-needle biopsy open biopsy CT guidance fluoroscopy ultrasound histology immunostains molecular studies Cincinnati Children's

Hashtags

#PediatricOncology #BoneTumors #Biopsy #InterventionalRadiology #CTImaging #Fluoroscopy #Ultrasound #DiagnosticYield #Histology #Immunostaining #MolecularPathology #RiskStratification #TargetedTherapy #PatientSafety #MedicalResearch #CancerCare #PediatricHealth #SurgicalTechniques #ClinicalGuidelines #BoneBiopsy #ImageGuidedProcedures #MinimallyInvasive

Transcript

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