Remote Ischemic Conditioning (RIC) Decreases the Incidence and Severity of Necrotizing Enterocolitis (NEC) - Validation in a Large Animal Model
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- High-frequency remote ischemic conditioning (every 12h) significantly reduced NEC incidence in piglets vs controls
- Low-frequency RIC (every 24h) showed no protective effect, suggesting dosing frequency is critical for efficacy
- RIC protocol: 4 cycles of 4-min arterial occlusion + reperfusion, initiated at 24 hours of life
- Study validates prior rat model findings in clinically-relevant large animal (piglet) NEC model
- Non-invasive limb ischemia may offer novel NEC prevention strategy for high-risk neonates
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RIC, or remote ischemic conditioning, has been shown to decrease rates of necrotizing enterocolitis in a rat model. But can it also work in a large animal model? I'm Alex Halpern, a research fellow from Children's National, and this is an article that you should know. Gadal used an established piglet neck model to try and answer this question. They randomly assigned piglets to either receive Rick or serve as controls. Rick was initiated at 24 hours of life and consisted of 4 cycles of 4 minutes of arterial occlusion, followed by reperfusion. These cycles were repeated every 24 hours in the low frequency group and every 12 hours in the high frequency group. 38 piglets were randomized into. Control group, 26 into the low frequency group and 22 into the high frequency group. When compared to controls, high frequency Rick significantly reduced the incidence of neck. However, low frequency Rick did not. So it seems like high frequency Rick protects against neck in a piglet model. Let us know what you think in the comments below.