Osteosarcoma
Everything in the library about osteosarcoma — built automatically from the recorded discussions that name it
Educational content from recorded physician discussions — not medical advice. Always talk to your child's care team about your child's situation.
Content of this collection
Evidence & Research
2 items
Update Course Rewind: 2021 Top Ten Key Takeaways
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The 9th annual Pediatric Surgery Update Course was held as a webinar on August 27, 2021. We had a lot of lively discussion and engaging presentations on the latest updates in pediatric surgery. In this video we are reviewing the top ten key
video16:02 · Oct 2021
Bailey Roberts, MD - Best of the Best in Pediatric Surgery 2024
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Watch IPSO's Dr. Bailey Roberts's presentation on “Extracellular vesicles from metastatic osteosarcoma contribute to creation of a pre-metastatic nich” at the 2024 Best of the Best in Pediatric Surgery event!
Moderators: Todd Ponsky, Cec
video8:39 · Feb 2024
Case-Based Learning
2 items
Update Course Rewind: Thoracotomy vs VATS for Lung Metastases
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There are recent updates about the management of lung metastases in osteosarcoma and deciding thoracotomy vs VATS is our topic for today. At the recent 2021 Pediatric Surgery Update Course, Dr. Anusua "Roshni" Dasgupta reviewed the latest l
video9:40 · Aug 2022
Update Course Rewind: Chest Wall Reconstruction 2024
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In this session from the 12th Annual Update Course in Pediatric Surgery, Dr. Margaret Mutch from Australia walks through the complexities of chest wall reconstruction following thoracic osteosarcoma resection in a pediatric patient.Key High
video5:32 · Aug 2025
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Every expert statement below comes from the recorded discussions, with its speaker and moment.
Bailey Roberts, MD - Best of the Best in Pediatric Surgery 2024
Osteosarcoma most commonly affects adolescents and young adults
epidemiologicalBailey Roberts1:08 ↗
Gross metastasis at the time of diagnosis is present about 20% of the time in osteosarcoma
epidemiologicalBailey Roberts1:11 ↗
The most common site of metastasis in osteosarcoma is in the lung
clinicalBailey Roberts1:11 ↗
Overall survival worsens from 80% to about 20% for metastatic osteosarcoma disease
epidemiologicalBailey Roberts1:19 ↗
Recurrence is very common in osteosarcoma, and the most common site of recurrence is in the lungs
clinicalBailey Roberts1:25 ↗
Extracellular vesicles are carriers of amino acids, proteins, mRNA or other forms of cellular communication
clinicalBailey Roberts1:38 ↗
EV content is unique and specific to the cells that released it, and therefore can be traced back to the cell type
clinicalBailey Roberts1:45 ↗
EVs are involved in the metastatic cascade and implicated as potential markers for disease diagnosis and staging
clinicalBailey Roberts1:52 ↗
EVs have been shown to change fibroblasts, inhibit T cell activity, and are involved in establishing a pre-metastatic niche
clinicalBailey Roberts1:59 ↗
K12 is a spontaneous osteosarcoma with low metastatic capability
clinicalBailey Roberts2:31 ↗
K7M2 is a highly metastatic osteosarcoma derived from a spontaneous osteosarcoma that went through two reiterations of harvesting spontaneous lung metastases and reimplanting them into the mouse
clinicalBailey Roberts2:35 ↗
The K7M2 cell line is more aggressive and causes death at a much higher rate than K12
clinicalBailey Roberts2:57 ↗
Pre-education with K7M2 EVs drastically increases the metastatic burden in the lungs of mice with K7M2 tumors
clinicalBailey Roberts3:59 ↗
Pre-education with K7M2 EVs increased the overall mortality during the five-week study period in mice with K7M2 tumors
clinicalBailey Roberts4:18 ↗
K7M2 EV education led to increased metastatic burden in mice with K12 tumors
clinicalBailey Roberts4:44 ↗
Pre-education with highly metastatic cell line EVs increases the metastasis seen in a normally low metastatic tumor
clinicalBailey Roberts5:01 ↗
No mice with K12 tumors died in the study period
clinicalBailey Roberts5:09 ↗
Extracellular vesicles delivered prior to tumor implantation from highly metastatic K7M2 increase the metastatic burden of K7M2 tumors
clinicalBailey Roberts5:14 ↗
Increased metastatic burden from extracellular vesicles decreases overall survival
clinicalBailey Roberts5:24 ↗
Extracellular vesicles from highly metastatic K7M2 increase the metastatic burden of less metastatic K12 tumors
clinicalBailey Roberts5:30 ↗
Extracellular vesicles can cause metastatic spread and therefore be a therapeutic target for osteosarcoma metastasis
opinionBailey Roberts5:39 ↗
All cells in the body release EVs, so we can't just generally target EVs and hope to decrease the establishment of a pre-metastatic niche
clinicalBailey Roberts6:27 ↗
IRF5 is a molecule being explored as a potential immunotherapy target in osteosarcoma EVs
clinicalBailey Roberts6:48 ↗
Surgically removing the primary tumor is the current standard of care for osteosarcoma
guidelineBailey Roberts7:10 ↗
There are certain membrane EV markers, but they're shared by all types of EVs
clinicalBailey Roberts7:31 ↗
The differences in EVs by cell type have more to do with the contents inside of them than the targets on them, which makes them difficult to target as far as treatment
clinicalBailey Roberts7:40 ↗
EVs are better for prognostic evaluation than treatment targeting
opinionBailey Roberts7:52 ↗
Studies in dogs show ability to take serum of dogs with osteosarcoma and determine their likelihood of metastasis based on the EVs
clinicalBailey Roberts7:57 ↗
Update Course Rewind: Chest Wall Reconstruction 2024
The institution has about 10 years of experience with chest wall reconstructions
clinicalMargaret Mutch0:16 ↗
Patient presented with back pain and difficulty walking
clinicalLizzie Lee0:25 ↗
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