Institutional Resources

The CuSTOM multi-disciplinary team works to accelerate discovery and development of new regenerative therapies and personalized medicine.

The Digestive Health Center conducts digestive disease research and makes discoveries related to pediatric digestive conditions. Learn more about our work.

General and thoracic surgery researchers study new therapies to treat fetal, congenital and pediatric conditions as early as possible.

We believe in science and compassion. Learn how our scientists conduct breakthrough research to improve the lives of children every day.

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Cincinnati Children’s is dedicated to keeping families, healthcare professionals, and the news media informed with the latest updates, discoveries, and institutional milestones.

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Background And Aims: We previously identified small molecules predicted to reverse an ileal gene signature for future Crohn's Disease (CD) strictures. Here we used a new human intestinal organoid (HIO) model system containing macrophages to

Background & Aims: Little is known about the prevalence of nonalcoholic fatty liver disease (NAFLD) among severely obese adolescents or factors that determine its development. We investigated the prevalence of NAFLD in a multicenter cohort

Introduction: The pathophysiology of type 2 diabetes (T2D) in youth differs from adults and conventional medical treatment approaches with lifestyle change, metformin, thiazolidinediones or insulin are inadequate. Metabolic bariatric surger

BMP signaling fine-tunes the co-differentiation of mesoderm and endoderm.The cellular composition in multilineage organoids resembles that of human fetal organs.Mesenchyme and endothelium co-developed within the organoids adopt organ-specif

Background And Aims: We previously identified small molecules predicted to reverse an ileal gene signature for future Crohn's Disease (CD) strictures. Here we used a new human intestinal organoid (HIO) model system containing macrophages to

Glucagon-like peptide-2 (GLP-2) is a gut hormone that is secreted in response to enteral feeding and stimulates small intestinal mucosal growth. We have previously shown that GLP-2 infusion acutely increases portal venous blood flow in TPN-

Obesity surgery · 2010