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Rhabdomyosarcoma
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Educational content from recorded physician discussions — not medical advice. Always talk to your child's care team about your child's situation.
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Unresectable large soft tissue sarcomas should be treated with preoperative radiation therapy and preoperative chemotherapy (previously only chemotherapy was recommended). — Andrea, Soft Tissue Sarcoma Rapid Fire: Update Course 2015 · 5:52
Soft Tissue Sarcoma Rapid Fire: Update Course 2015
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Dr. Andrea Hayes Jordan discusses soft tissue sarcomas. Her presentation covers ovarian masses, ovarian germ cell tumors and treatment, bilateral ovarian disease, ovarian preservation technique, IRS clinical grouping of soft tissue sarcomas
video8:27 · Jan 2019
Incisional biopsy or image-guided core needle biopsy is recommended for extremity rhabdomyosarcoma, taking into account tumor location and relationship to neurovascular structures. — Emily Christison-Lagay, Technical approaches to rhabdomyosarcoma management: APSA Cancer Committee case series · 3:26
Technical approaches to rhabdomyosarcoma management: APSA Cancer Committee case series
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Panel discussion on rhabdomyosarcoma with Cancer committee members David Rodeberg, Roshni Dasgupta, Timothy Lautz, Emily Christison-Lagay and Daniel Rhee from the APSA 2020 virtual meeting.
video17:35 · Oct 2026
GnRH agonist therapy has not demonstrated clear fertility preservation benefit in pediatric patients and is not recommended as first-line by ASCO. — Julie Rios, Oncofertility Ovarian Salvage · 1:08
Oncofertility Ovarian Salvage
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At the 7th Annual Pediatric Surgery Update Course, Dr. Julie Rios discusses ovarian salvage.
video · Mar 2020
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Expert statements from the recordings in this collection.
Soft Tissue Sarcoma Rapid Fire: Update Course 2015
Half of soft tissue sarcomas are rhabdomyosarcomas, and the other half are non-rhabdomyosarcomas.
epidemiologicalAndrea0:00 ↗
Prognosis in rhabdomyosarcoma varies depending on site, with abdominal, pelvic, and retroperitoneal tumors having the worst survival and orbital rhabdomyosarcomas having the best survival.
clinicalAndrea0:25 ↗
Stage 1 rhabdomyosarcoma includes favorable sites (vaginal and paratesticular), while stages 2, 3, and 4 are unfavorable sites with various amounts of disease.
clinicalAndrea0:50 ↗
Even a small tumor in the extremity or abdomen can only achieve stage 2 at best.
clinicalAndrea1:02 ↗
Clinical grouping in rhabdomyosarcoma depends on surgical extent: group 1 is complete removal, group 2 is microscopic residual, and group 3 is biopsy only.
clinicalAndrea1:14 ↗
Group 1 and 2 rhabdomyosarcoma patients have an excellent prognosis, while group 3 patients do more poorly.
clinicalAndrea1:30 ↗
A large tumor that a surgeon cannot resect is a biologic determination, and attempting resection with high morbidity will not improve the patient's outcome.
opinionAndrea1:45 ↗
Five centimeters is the cutoff for low-risk versus high-risk patients in soft tissue sarcoma.
clinicalAndrea2:09 ↗
Sentinel lymph node biopsies are now required for all rhabdomyosarcoma patients with trunk or extremity tumors.
guidelineAndrea3:18 ↗
In rhabdomyosarcoma, completion node dissection is not performed after sentinel lymph node biopsy; patients receive radiation therapy instead.
guidelineAndrea3:34 ↗
Alveolar rhabdomyosarcoma patients should receive chemotherapy after biopsy, which typically reduces the tumor to approximately 1 centimeter, making resection with negative margins easier.
clinicalAndrea3:53 ↗
Sentinel lymph node mapping should be performed at the time of re-excision in rhabdomyosarcoma.
guidelineAndrea4:07 ↗
Forty to fifty percent of biopsied lymph nodes are positive in rhabdomyosarcoma.
epidemiologicalAndrea4:39 ↗
Clinically negative lymph nodes may be positive in rhabdomyosarcoma, which is why sentinel node biopsy is performed.
clinicalAndrea4:39 ↗
Positive lymph nodes in rhabdomyosarcoma have a worse prognosis and require radiation therapy.
clinicalAndrea4:39 ↗
In non-rhabdomyosarcoma soft tissue sarcoma, histological grade is now critical for treatment planning.
guidelineAndrea4:54 ↗
Large soft tissue sarcoma tumors should be biopsied first and treated with chemotherapy before resection.
guidelineAndrea4:54 ↗
Soft tissue sarcomas have been identified as chemotherapy-sensitive or chemotherapy-insensitive, which changes treatment approach.
clinicalAndrea5:13 ↗
Low-grade soft tissue sarcoma tumors require only resection and observation, with no need for radiation or chemotherapy.
guidelineAndrea5:21 ↗
If a low-grade soft tissue sarcoma is resected with positive margins, the patient will receive adjuvant radiation therapy.
guidelineAndrea5:38 ↗
Unresectable large soft tissue sarcomas should be treated with preoperative radiation therapy and preoperative chemotherapy (previously only chemotherapy was recommended).
guidelineAndrea5:52 ↗
Small soft tissue sarcoma tumors less than 5 centimeters should be resected with attempts to achieve negative margins.
guidelineAndrea6:10 ↗
Chemotherapy-sensitive soft tissue sarcomas include synovial sarcoma and undifferentiated sarcoma.
clinicalAndrea6:10 ↗
Chemotherapy-insensitive soft tissue sarcomas include alveolar soft part sarcoma, malignant epithelioid sarcoma, and clear cell sarcoma, all of which are high-grade tumors.
clinicalAndrea6:28 ↗
For chemotherapy-insensitive soft tissue sarcomas, the surgeon and radiation therapist are the primary treaters.
clinicalAndrea6:28 ↗
High-risk soft tissue sarcoma patients receive preoperative radiation and chemotherapy.
guidelineAndrea6:48 ↗
An Italian study showed that a 5 centimeter tumor in a child less than 3 years old is equivalent to a 3 centimeter tumor in larger patients, suggesting 3 centimeters as the cutoff for excision versus biopsy in toddlers.
Host summaryAndrea summarizing the discussion — not the host's own clinical position6:54 ↗
Sentinel lymph node biopsy should always be performed if lymph nodes are clinically negative by imaging.
guidelineAndrea7:15 ↗
Positive lymph nodes receive radiation to the lymph node basin, and completion node dissection is not required.
guidelineAndrea7:15 ↗
Non-rhabdomyosarcoma tumors with negative margins after resection do not need chemotherapy if they are low-grade.
guidelineAndrea7:25 ↗
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