Congenital Aqueductal Stenosis

Everything in the library about congenital aqueductal stenosis — built automatically from the recorded discussions that name it

episodes total cited expert statements Updated Sep 25, 2026

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Fundamentals 1 item

2024 Fetal Care Center Frontiers in Fetal Neurology Day 1 - Introduction

Dr. Charu Venkatesen and Dr. Kara Markham opents Day 1 of the Frontiers in Fetal Neurology 2-day interactive webinar series.

video2:56 · Oct 2024

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Surgical Management 1 item

2024 Fetal Care Center Frontiers in Fetal Neurology Day 1 - Dr. Jesse Skoch

Dr. Jesse Skoch speaks on the Surgical management of Congenital Aqueductal Stenosis on Day 1 of the Frontiers in Fetal Neurology 2-day interactive webinar series.

video19:51 · Oct 2024

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Evidence & Research 1 item

2024 Fetal Care Center Frontiers in Fetal Neurology Day 1 - Dr. Charu Venkatesen

Dr. Charu Venkatesen speaks on the outcomes of patients with prenatal diagnosis of Congenital Aqueductal Stenosis on Day 1 of the Frontiers in Fetal Neurology 2-day interactive webinar series.

video12:51 · Oct 2024

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Case-Based Learning 1 item

2024 Fetal Care Center Frontiers in Fetal Neurology Day 1 - Hour 1 Q&A

Dr. Charu Venkatesen, Dr. Jesse Skoch, and. Dr. Jose Peiro discuss the hour 1 sessions and answers questions from the audience.

video9:06 · Oct 2024

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2024 Fetal Care Center Frontiers in Fetal Neurology Day 1 - Hour 1 Q&A

The complex category in the Children's Hospital study included any case with any other anomaly, including genetic anomalies (aneuploidies, trisomy 13/18), extracranial findings, and syndromic findings, creating a heterogeneous group.

clinical0:47 ↗

Current counseling practice tends to combine isolated aqueductal stenosis cases (without suspected genetic cause) with complex cases in a broad-strokes approach, which may not be the appropriate approach.

opinion0:47 ↗

Conventional endoscopes for ETV are usually about 6 millimeters in diameter.

clinical2:07 ↗

For fetal ETV cases, 2.4 millimeter scopes are being used in clinical studies.

host_summary2:07 ↗

The fetal ETV scope is a 2.4 mm sharp-tip fetoscope with a 1.3 mm camera and a working channel, the same equipment used for placing tracheal balloons in CDH fetuses.

clinical2:22 ↗

The proposed gestational age for fetal ETV in phase one human studies is 24-25 weeks, following diagnosis around 20-21 weeks and genetic workup, similar to timing for spina bifida repair.

clinical3:11 ↗

Intervention between 25 and 30 weeks gestational age is considered acceptable for cases with delayed diagnosis, allowing time for brain recovery in utero.

opinion3:11 ↗

The fetal ETV trial requires an FDA IND (Investigational New Drug application) because it is a risky procedure, even though no drug is used and no device is left behind.

guideline4:03 ↗

The goal is to begin a pilot study for safety and feasibility of fetal ETV next year, involving collaboration between fetal surgery and neurosurgery teams.

clinical4:03 ↗

Acetazolamide can reduce CSF production by approximately 15% at best.

clinical5:29 ↗

Acetazolamide may allow delaying intervention by one to two months in borderline, slowly progressing cases to reach a better category for ETV.

opinion5:29 ↗

Acetazolamide has sufficient safety experience and electrolyte monitoring protocols to be used as a temporizing measure in appropriate patients.

clinical5:29 ↗

Acetazolamide cannot be expected to be a game changer in rapidly progressing hydrocephalus cases.

opinion5:29 ↗

Early postnatal ETV has a high failure rate in newborns with congenital aqueductal stenosis.

clinical5:29 ↗

In a study by Rus, type 2 slowly progressive hydrocephalus patients treated with delayed ETV had the same neurologic outcomes as patients who were shunted earlier.

epidemiological5:29 ↗

For stable postnatal patients not showing signs of rapid progression, there is no convincing data that earlier intervention is always better in a linear fashion.

opinion5:29 ↗

For patients showing active progression with increasing pressure and damage, sooner intervention is better than waiting.

opinion5:29 ↗

The primary benefit of fetal ETV may be developmental changes rather than preventing procedure failure, as many fetal ETV patients may still experience postnatal failure.

opinion5:29 ↗

In postnatal treatment, the timing of intervention (earlier versus slightly later) is probably not as critical because the damage is already done and the condition is stable.

opinion8:12 ↗

In fetal cases, timing is very critical because early intervention can potentially avoid pressure and allow better brain development.

opinion8:12 ↗

The ETV fenestration can close in both neonates and fetuses, which is a concern for fetal intervention.

clinical8:12 ↗

Maintaining decompression for 6-7 weeks in utero without pressure is beneficial even if postnatal redo ETV or shunt placement is needed, because the brain will have developed better.

opinion8:12 ↗

The goal of fetal ETV is not to completely fix the hydrocephalus but to temporize and achieve better brain development, even if the intervention is temporary.

opinion8:12 ↗

2024 Fetal Care Center Frontiers in Fetal Neurology Day 1 - Introduction

Day 1 session 1 (12:00-1:00 PM) covers congenital aqueductal stenosis, including outcomes and fetal MRI findings