Colorectal Cancer
Everything in the library about colorectal cancer — built automatically from the recorded discussions that name it
Educational content from recorded physician discussions — not medical advice. Always talk to your child's care team about your child's situation.
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Evidence & Research
1 item
Best of the Best Gen Surg - Development of postoperative local tumors and distant metastases in diet, genetics and microbiome-dependent in a mouse model of colorectal cancer recurrence - Dr. Morgan
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Listen to Ryan Morgan gave his presentation of "Development of postoperative local tumors and distant metastases in diet, genetics and microbiome-dependent in a mouse model of colorectal cancer recurrence" at the first ever Best of the Best
video12:40 · Sep 2022
In-Depth Reviews
3 items
Colorectal Cancer
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An interactive discussion about colorectal cancer between Jeffrey Ponsky, MD and Conor Delaney, MD, PhD. Dr. Delaney, is the chairman of the Digestive Disease
podcast26:42 · Jul 2026
Colorectal Cancer
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An interactive discussion about colorectal cancer between Jeffrey Ponsky, MD and Conor Delaney, MD, PhD. Dr. Delaney, is the chairman of the Digestive Disease
podcast26:42 · Jul 2026
Colorectal Cancer
Listen →
An interactive discussion about colorectal cancer between Jeffrey Ponsky, MD and Conor Delaney, MD, PhD. Dr. Delaney, is the chairman of the Digestive Disease and Surgery Institute at Cleveland Clinic, Cleveland, OH. Dr. Delaney is also a p
podcast26:42 · Jul 2026
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Every expert statement below comes from the recorded discussions, with its speaker and moment.
Best of the Best Gen Surg - Development of postoperative local tumors and distant metastases in diet, genetics and microbiome-dependent in a mouse model of colorectal cancer recurrence - Dr. Morgan
Colorectal cancer is a leading cause of cancer deaths, particularly in cases of recurrence.
epidemiologicalRyan Morgan0:45 ↗
Traditional paradigms suggest recurrences are due to either incomplete resection or occult metastases left behind at the time of surgery.
host_summaryRyan Morgan0:45 ↗
Exfoliated cancer cells in the lumen of the bowel may be a source of recurrence.
host_summaryRyan Morgan0:58 ↗
In the 1980s, UMLB showed that exfoliated cancer cells are present and viable at the time of surgery.
host_summaryRyan Morgan1:04 ↗
Experimental cells could cross a watertight anastomosis in a mouse model.
host_summaryRyan Morgan1:09 ↗
Rectal washout decreases rates of local recurrence after rectal cancer resection.
host_summaryRyan Morgan1:14 ↗
When the primary colorectal tumor is resected, exfoliated cells remain behind within the lumen of the bowel and interact with the anastomotic microenvironment.
clinicalRyan Morgan1:39 ↗
Multiple factors can influence the anastomotic environment, including diet, the microbiome, and the tumor genetic background.
clinicalRyan Morgan1:48 ↗
A high-fat diet and its impact on the microbiome would alter the anastomotic environment and change the metastatic potential of cells.
clinicalRyan Morgan2:04 ↗
AKPT and KPN organoid cell lines demonstrate a wide range of metastatic potential in animal models.
host_summaryRyan Morgan2:15 ↗
AKPT mice showed significantly higher rate of tumor formation with a high-fat diet compared to mice given a chow diet by 56 days.
clinicalRyan Morgan3:35 ↗
KPN mice showed no significant difference in tumor formation based on diet, with an opposite trend towards higher rates in the chow diet.
clinicalRyan Morgan3:46 ↗
AKPT mice given a high-fat diet had significantly decreased survival compared to those on a chow diet.
clinicalRyan Morgan4:08 ↗
KPN mice did not show any similar survival trend, suggesting that response to diet was at least in part based on the organoid genetic background.
clinicalRyan Morgan4:14 ↗
In germ-free mice, the high-fat diet-associated microbiome significantly increased the rate of postoperative tumor development (40% vs 10-12% in control and chow FMT groups).
clinicalRyan Morgan4:57 ↗
Two-week diet reversal period was insufficient; mice in the reversal group continued to have poor survival and high tumor rates similar to the high-fat diet group.
clinicalRyan Morgan5:50 ↗
Six-week diet reversal resulted in significantly increased survival and tumor rate similar to chow-fed mice, suggesting the response to diet and its reversal was time dependent.
clinicalRyan Morgan6:01 ↗
High-fat diet mice showed derangement of microbiome with overabundance of Alobaum and bloom of pathogenic bacteria such as Proteus, E. coli, and Shigella on postoperative day 7.
clinicalRyan Morgan6:30 ↗
The diet reversal group microbiome composition closely mirrored the chow group both in baseline composition and in response to surgery.
clinicalRyan Morgan6:45 ↗
Preoperative diet manipulation reduces tumor formation, suggesting a clinically relevant role for diet rehabilitation in colorectal cancer treatment.
opinionRyan Morgan7:23 ↗
The no-touch isolation technique of Turnbull was important in demonstrating the need to avoid handling the tumor.
host_summary8:20 ↗
Combined mechanical and antibiotic bowel preparation preoperatively decreases rates of colorectal cancer recurrence.
host_summaryRyan Morgan9:23 ↗
Preliminary in vitro data shows AKPT cells have more proliferative response to secondary bile acids (like deoxycholic acid) compared to KPN cells.
clinicalRyan Morgan11:05 ↗
Secondary bile acids and deoxycholic acid metabolites are exclusively bacterially produced.
clinicalRyan Morgan11:05 ↗
Colorectal Cancer
Colonoscopy is still the best test available for colon cancer detection, finding the vast majority of cancers and polyps, though not perfect.
clinicalConor Delaney1:15 ↗
Serrated adenomas (previously misclassified as hyperplastic polyps) have good evidence of genetic predisposition and tie into many family cancer syndromes.
clinicalConor Delaney2:03 ↗
Serrated polyps have a very high risk of cancer and require family assessment to determine if patients have a family cancer syndrome.
clinicalConor Delaney2:03 ↗
Serrated adenomas are often flat and difficult to see; retroflexion in the cecum is useful because they are often on the inferior or superior side of the valve or on folds.
clinicalConor Delaney3:26 ↗
Six centimeters from the anal verge can be mid-rectum in a small patient (90-pound, 80-year-old female) or close to the dentate line in a large patient (6'6", 300 pounds).
clinicalConor Delaney4:59 ↗
Distal margin requirements for rectal resection: 5 centimeters if possible, 2 centimeters if possible, and for very lowest tumors perhaps 1 centimeter as long as they are not poorly differentiated.
guidelineConor Delaney4:59 ↗
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