Decreased β-catenin Protein in Lungs From Human Congenital Diaphragmatic Hernia Archival Pathology Specimens: A Case-control Study
Author / Expert
Martin A. Prusinkiewicz, Chanhyeok Park, Claire Cheung, Ying Jie Li, Bethany Poon, Erik D. Skarsgard, Pascal M. Lavoie, Anna F. Lee, Martina Mudri
Topic overview
Lung hypoplasia contributes to congenital diaphragmatic hernia (CDH) associated morbidity and mortality. Changes in lung wingless-type MMTV integration site family member (Wnt)-signalling and its downstream effector beta-catenin (CTNNB1), which acts as a transcription coactivator, exist in animal CDH models but are not well characterized in humans. We aim to identify changes to Wnt-signalling gene expression in human CDH lungs and hypothesize that pathway expression will be lower than controls.
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