Microinjection With Nanoparticles to Deliver Drugs in Prenatal Lung Explants - A Pilot Study for Prenatal Therapy in Congenital Diaphragmatic Hernia
Author / Expert
Yuichiro Miyake, Wai Hei Tse, Jia Qi Wang, Daywin Patel, Arzu Ozturk, Atsuyuki Yamataka, Richard Keijzer
Topic overview
Fetoscopic endoluminal tracheal occlusion (FETO) improves the survival rate in fetuses with severe congenital diaphragmatic hernia (CDH). We hypothesize that prenatal therapies into the trachea during FETO can further improve outcomes. Here, we present an ex vivo microinjection technique with rat lung explants to study prenatal therapy with nanoparticles.
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