Circular RNA MTCL1 targets SMAD3 by sponging miR-145‐5p for regulation of cell proliferation and migration in Hirschsprung’s disease

This molecular study identifies a circular RNA (Circ-MTCL1) regulatory pathway involved in Hirschsprung's disease pathogenesis. Researchers demonstrate that Circ-MTCL1 acts as a microRNA sponge to regulate SMAD3 expression, affecting enteric neural cell proliferation and migration—offering potential insights into the epigenetic mechanisms underlying abnormal ENS development.