Ephrin-B1, -B2, and -B4 Expression is Decreased in Developing Diaphragms and Lungs of Fetal Rats with Nitrofen-Induced Congenital Diaphragmatic Hernia

Study demonstrates that ephrin-B1, -B2, and -B4 expression is significantly reduced in developing diaphragms and lungs of nitrofen-exposed fetal rats with CDH. Decreased ephrin signaling disrupts epithelial-mesenchymal interactions critical for diaphragmatic closure and lung branching, providing molecular insight into CDH-associated pulmonary hypoplasia pathogenesis.