Interstitial cells of Cajal: clinical relevance in pediatric gastrointestinal motility disorders

This comprehensive review examines interstitial cells of Cajal (ICCs), the pacemaker cells that coordinate gut motility, and their role in pediatric gastrointestinal disorders. The article covers ICC embryology, distribution, and function, while detailing ICC deficiencies in conditions like Hirschsprung disease, intestinal neuronal dysplasia, and congenital smooth muscle disorders.