The m6A methyltransferase METTL3 affects cell proliferation and migration by regulating YAP expression in Hirschsprung disease

This molecular study identifies METTL3-mediated m6A methylation as a key regulator in Hirschsprung disease pathogenesis, demonstrating that reduced METTL3 expression impairs neural crest cell proliferation and migration through YAP pathway dysregulation. The findings reveal a novel epigenetic mechanism underlying enteric nervous system development defects in HSCR.