Correlation Between Postoperative Antimicrobial Prophylaxis Use and Surgical Site Infection in Children Undergoing Nonemergent Surgery

Multicenter study of 40,611 pediatric surgical patients found no correlation between postoperative antibiotic prophylaxis continuation and surgical site infection rates across 93 hospitals. Despite 42% of patients receiving postoperative prophylaxis with 190-fold variation between institutions, SSI rates remained unaffected when adjusted for procedure type and patient characteristics.