Recognizing Life-Threatening Bleeding in Pediatric Trauma: A Standard for When to Activate Massive Transfusion Protocol

Study establishes 20 mL/kg/hour transfusion threshold as optimal trigger for activating massive transfusion protocols in pediatric trauma, demonstrating 70% sensitivity for mortality prediction. Children exceeding this critical administration threshold face 3.4-fold increased mortality risk and require aggressive hemostatic resuscitation.