Clinical trials in desmoid-type fibromatosis in children and adults: A systematic review

Systematic review of 14 clinical trials examining desmoid-type fibromatosis treatment in pediatric and adult populations reveals wide variation in tumor response rates and highlights treatment disparities between age groups, primarily due to limited tyrosine kinase inhibitor access in pediatric oncology. The review emphasizes the need for more randomized trials and patient-reported outcome studies in this chronic, quality-of-life-impacting condition.