Outcomes of children with well-differentiated fetal hepatoblastoma treated with surgery only: Report from Children's oncology group trial, AHEP0731

Children's Oncology Group trial AHEP0731 demonstrates that hepatoblastoma with 100% well-differentiated fetal histology completely resected at diagnosis achieves 100% survival with surgery alone, eliminating the need for adjuvant chemotherapy. This finding supports risk-stratified treatment de-escalation for this favorable histologic subtype, with implications for reducing treatment toxicity in select pediatric liver cancer patients.