Aberrant expression of LINC00346 regulates cell migration and proliferation via competitively binding to miRNA-148a-3p/Dnmt1 in Hirschsprung’s disease

Study identifies LINC00346 as a downregulated long noncoding RNA in Hirschsprung's disease that regulates enteric neural crest cell development through a competing endogenous RNA mechanism. LINC00346 acts as a molecular sponge for miR-148a-3p, modulating Dnmt1 expression and affecting cell proliferation, migration, and apoptosis in disease pathogenesis.