Sildenafil Attenuates Intestinal Injury in Necrotizing Enterocolitis Independently of Endothelial Nitric Oxide Synthase
Author / Expert
Chelsea E. Hunter, Brian D. Hosfield, Fikir M. Mesfin, Anthony R. Pecoraro, Jianyun Liu, W. Christopher Shelley, Krishna Manohar, Troy A. Markel
Topic overview
Necrotizing enterocolitis (NEC) is a devasting intra-abdominal disease that occurs primarily in preterm neonates. Clinically, NEC presents as feeding intolerance, abdominal distention, and bloody stools, which can quickly progress to sepsis and intestinal perforation [1]. Mortality from NEC remains high and accounts for 10-21% of all deaths in premature babies [2]. Multiple factors have been shown to play a role in its development, including prematurity, formula feeds, and intestinal dysbiosis [3, 4].
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