The natural history of prenatally diagnosed congenital pulmonary airway malformations and bronchopulmonary sequestrations

Retrospective study of 66 prenatally diagnosed CPAM/BPS cases over 18 years found that 56% regressed during gestation and 69% were managed conservatively with median 4-year follow-up. Mediastinal shift, high CVR, and large lesion size predicted surgical need, supporting watchful waiting for asymptomatic neonates.