Metastatic Human Hepatoblastoma Cells Exhibit Enhanced Tumorigenicity, Invasiveness and a Stem Cell-Like Phenotype

Researchers developed HLM_3, a metastatic hepatoblastoma cell line derived from serial murine injections, which demonstrates increased tumorigenicity, invasiveness, and stem cell characteristics compared to parent cells. This model exhibits chemotherapy resistance and provides a valuable tool for studying metastatic mechanisms and testing novel therapeutic approaches in pediatric liver cancer.