Use of thromboelastography in children on extracorporeal membrane oxygenation
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Topic overview
ABSTRACT
Introduction
: Extracorporeal membrane oxygenation (ECMO) profoundly impacts inflammatory and coagulation pathways, and strict monitoring is essential to guide therapeutic anticoagulation. Thromboelastography (TEG) offers a global evaluation of whole blood hemostatic system components and may be a valuable measurement of hemostatic function in these patients. There is a paucity of data correlating TEG parameters with standard measures of coagulation in heparinized pediatric patients.
Methods
: Children on ECMO during a 10-year period were retrospectively reviewed. Standard measures of coagulation were matched to TEGs drawn within 30 minutes of each other.
Results
: Out of 296 unique patients with 331 ECMO runs, 74.3% (n=246) had at least one set of matched laboratory samples for a total of 2502 matched samples. The aPTT correlated with R-time (p
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