Serine-Threonine Kinase Receptor Associate Protein (STRAP) Confers an Aggressive Phenotype in Neuroblastoma via Regulation of Focal Adhesion Kinase (FAK)

STRAP protein overexpression in neuroblastoma correlates with high-risk disease and poor survival by activating focal adhesion kinase (FAK) signaling pathways. Experimental models demonstrate that STRAP drives aggressive tumor behavior including increased proliferation and stem-like characteristics, which can be reversed with FAK inhibition.