The effect of intravenous lipid emulsions and mucosal adaptation following massive bowel resection

Space: StayCurrentMD Author: Shun Onishi, Tatsuru Kaji, Seiro Machigashira, Waka Yamada, Ryuta Masuya, Kazuhiko Nakame, Masato Kawano, Keisuke Yano, Koji Yamada, Takafumi Kawano, Motoi Mukai, Takako Yoshioka, Akihide Tanimoto, Satoshi Ieiri Published: 2018-10-08

Author / Expert

Shun Onishi, Tatsuru Kaji, Seiro Machigashira, Waka Yamada, Ryuta Masuya, Kazuhiko Nakame, Masato Kawano, Keisuke Yano, Koji Yamada, Takafumi Kawano, Motoi Mukai, Takako Yoshioka, Akihide Tanimoto, Satoshi Ieiri

Topic overview

Abstract

Aims and objectives

Fish oil (FO) lipid emulsion and a new lipid emulsion (SMOF) are important treatments for intestinal failure-associated liver disease. We evaluated the efficacy of FO and SMOF lipid emulsion on intestinal mucosal adaptation using a total parenteral nutrition (TPN)-supported rat model of short bowel syndrome.

Material & methods

Sprague–Dawley rats underwent jugular vein catheterization and 90% small bowel resection and were divided into three groups: TPN with soy bean oil lipid emulsion (SO group), FO lipid emulsion (FO group), or SMOF (SMOF group). On day 13, the rats were euthanized, and the small intestine was harvested. The microscopic morphology and crypt cell proliferation rate (CCPR) were then evaluated.

Results

The villus height of the ileum in the SMOF group was significantly higher than in the SO group. The crypt depth of the intestine in the SMOF group was significantly lower than in the SO group. The CCPRs of the intestine in the FO and SMOF groups were both higher than in the SO group.

Conclusions

Lipid emulsion affected the bowel morphology, such as the mucosa as well as the intestinal smooth muscle. Further studies are needed to clarify the mechanisms.