Transserosal migration of enteric neural stem cells: Developing an avian colon model

Researchers developed an avian colon model using quail embryo hindguts grafted onto chicken chorioallantoic membranes to study transserosal stem cell migration for treating enteric neuropathies like Hirschsprung disease. The model successfully maintained viable colon tissue with intact serosa for 8 days, providing a cost-effective platform for testing stem cell delivery methods across large intestinal surface areas.