KLF5 promotes KIF1A expression through transcriptional repression of microRNA-338 in the development of pediatric neuroblastoma

This study identifies a novel regulatory axis in pediatric neuroblastoma where transcription factor KLF5 suppresses microRNA-338, leading to increased KIF1A expression and activation of the Hedgehog signaling pathway. The findings reveal miR-338 as a tumor suppressor and potential therapeutic target, with its overexpression significantly inhibiting neuroblastoma cell growth both in vitro and in vivo.