Vitamin A can ameliorate fibrosis of liver in an established rat model of biliary atresia and Kasai portoenterostomy

Experimental study in rats demonstrates that vitamin A significantly reduces liver fibrosis progression after Kasai portoenterostomy for biliary atresia, outperforming prednisolone and ursodeoxycholic acid. Vitamin A uniquely decreased both α-SMA expression and histological fibrosis grade, suggesting potential as adjuvant therapy to preserve liver function post-KPE.