Ketorolac Use and Risk of Bleeding After Appendectomy in Children with Perforated Appendicitis

Retrospective cohort study of 55,603 children demonstrates that perioperative ketorolac alone does not increase bleeding risk after appendectomy for perforated appendicitis. However, combined ketorolac-ibuprofen use and extended ketorolac duration were associated with increased transfusion risk, informing perioperative NSAID protocols.